International Journal of Pharmacy and Pharmacology

Abstract: This work presents results of the preparation and characterization of nanoparticles for entrapping cytarabine, a chemotherapeutic agent. The particle size analysis indicated a uniform particle size. The study of the release of drug from nanoparticles exhibited a prolonged release profile as studied over a period of 16 hours. The drug release was constant from the 10th to the 16th hours, which showed that the formulation was successful for long-term treatment. The drug entrapment efficiency of the nanoparticles havi…

Abstract: The effectiveness of the disinfectant hibitane on some microorganisms associated with nosocomial infections were assessed at various use-dilutions of 1: 10, 1: 100, 1: 200 and 1: 2000 constituted using aqueous ethanol and 10% serum solutions. The shapes of the death curves were qualitatively similar for all the organisms exhibiting an initial shoulder (lag), the duration of which depended on hibitane® concentration used and this was closely followed by an exponential order of death. Alcoholic solutions were much mo…

Abstract: Grewia gum has been evaluated as a binder in paracetamol tablet formulations. Compressional properties of the formulations were analyzed using density measurements and the compression equations of Heckel and Kawakita as assessment parameters. Formulations containing Grewia gum as a binder show a slower onset and lower amount of plastic deformation than those containing PVP. The Db values for formulations containing Grewia gum, increased with increased concentration up to 4% w/w. Formulations containing Grewia gum w…

Abstract: Antimicrobial properties of leaf extracts of Senna obtusifolia (L) were investigated against both clinical and laboratory isolates of both bacteria and fungi using the disc diffusion method. Acetone extracts (12 mm zone diameter of inhibition, MIC 200 g/mL and MBC 300 g/mL) demonstrated the highest activity, followed by dichloromethane (8 mm zone diameter of inhibition, MIC 300 g/mL and MBC 400 g/mL), methane (7 mm zone diameter of inhibition, MIC 400 g/mL and MBC 400 g/mL) and hexane (6 mm zone diameter of inhibit…

Abstract: The mitochondrial permeability transition (MPT) is considered to contribute substantially to the regulation of normal mitochondrial metabolism and plays as an important mediator of cell death. MPT is regulated in a tissue specific manner. The importance of this work is highlighted by the fact that knowledge regarding liver MPT may serve as important determinants of the physiological state of the liver. Our results suggest that liver mitochondria exhibit a cyclosporin A sensitive, exogenous calcium mediated full sca…

Abstract: This study investigated the quality of atorvastatin calcium tablets marketed in Lagos, Nigeria, by evaluating and comparing their physico-chemical profiles. Evaluation of physico-chemical parameters viz: uniformity of weight, hardness, friability and disintegration test was carried out according to British Pharmacopoeia. Assay of active ingredient and in-vitro dissolution evaluation were conducted using USP Apparatus 2 satisfying the general conditions for film tablets as stipulated in official books. Tablets and d…

Abstract: Being guided by the methodological principles of "chiral switches", the synthesis of S- and R-enantiomers of 1-allyl-4-hydroxy-6,7-dimethoxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid (1-ethylpyrrolidin-2-ylmethyl)-amide hydrochloride has been carried out. According to the results of the biological research, it has been found that the ability of the optical isomers obtained to block opioid receptors remains at the racemate level. It is important for future research conclusion – the asymmetrical carbon atom in the…

Abstract: The simple methods for obtaining have been suggested and the synthesis of new hydroxyalkylamides of 1-(2-cyanoethyl)-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid and their derivatives has been carried out by alcoholic hydroxyl. The peculiarities of the spatial structure of the given group of substances have been considered by an example of 3-isopropoxypropylamide. The research results of the analgesic activity of all the compounds synthesized are given; they confirm the expediency of searching new painkil…

Abstract: Wild and cultivated olive has been used in the treatment of many diseases ethnopharmacologically in Pakistan. In the present manuscript we have demonstrated the antimicrobial effects of various fractions of leaves of Olea cuspidata and Olea europaea. The leaves of O. cuspidata Wall and O. europaea L. (Family: Oleaceae) were extracted successively with four different organic solvents. These crude extracts were assessed for antibacterial activities against eight different bacterial human pathogens that is, Staphyloco…