International Journal of Pharmacy and Pharmacology

Abstract: Studies’ reports in both humans and experimental animals have supported the use of methionine as an effective antidote to counteract the manifestation of hepatotoxicity, which is a common occurrence of acetaminophen at overdose levels of exposure. This study was embarked on to test the hepatoprotective effect of methionine in acetaminophen tablets, produced by a leading paracetamol brand in Nigeria especially in ameliorating the hepatocellular damage for which acetaminophen is noted for. Ten percent methionine was…

Abstract: Lactoperoxidase is a peroxidase enzyme found in milk. This enzyme has antimicrobial and antioxidant properties. It is fairly heat resistant and was widely used as an indicator of over pasteurization of milk. In the present study, bovine lactoperoxidase (LPO) was purified from skimmed milk using amberlite-CG-50-H+ resin, CM-sephadex-C-50 ion-exchange chromatography and sephadex-G-100 gel filtration chromatography. Enzyme activity was determined using 2, 2-azino-bis-diammonium salt as a chromogenic substrate at pH 6…

Abstract: In the present study, two sustained release solid and semi-solid matrices were developed using Hydroxypropyl methyl cellulose (HPMC) and Gelucire derivative, Gelucire 50/30. The purpose of the study was in vitro and in vivo correlation of these two sustained release formulations with SR capsules available in market and to know that for how long the preparation containing HPMC and Gelucire work in the body as compared to the product circulating in the market, so for this two formulations were developed such as solid…

Abstract: PI3K/Akt signal pathway was blocked by Wortmannin, a specific inhibitor of phosphoinositide-3 kinase (PI3K), and the effects of intestinal trefoil factor (ITF) on PI3K and caspase-3/9 in newborn rats with necrotizing enterocolitis (NEC) were investigated to explore the protective mechanism of ITF against NEC. Experimental NEC was induced by exposure to hypoxia for 60 sec followed by cold stress at 4°C for 10 min. A total of 50 One-day-old Wistar rats were randomly divided into five groups : group A, NEC+NS; group B…

Abstract: Castor Bean (Ricinus communis, Family Euphorbiaceae) ethanol extraction (CBE) possesses potent antifertility effect, but the absorption of it is limited. Therefore, this study was aimed to prepare CBE microparticles for targeted drug effect. Poly (toluene-2, 4-di-isocyanate and ethylene alcohol) (TDI-EA) microparticles loaded with CBE were prepared by Interracial polymerization, a semi-industrial technique capable of encapsulating fragile molecules maintaining their native properties. The effects of several paramet…

Abstract: The leaves and rhizomes of Alpinia scabra (Zingiberaceae) were investigated for their cytotoxic effect against selected human cancer cell lines, namely MCF7 (hormone-dependant breast carcinoma cell line), HT29 (colon carcinoma cell line) and SKOV-3 (ovarian cancer cell line) by using an in vitro neutral red cytotoxicity assay. The methanol extracts of both leaves and rhizomes did not show active cytotoxic activity against the selected cancer cell lines. The n-hexane extract of the leaves exhibited remarkable cytoto…

Abstract: The most important pharmacologically active constituents in propolis are flavanoids with a broad spectrum of biological activities varying with their chemical composition. Propolis chemical composition depends on the floral and geographical origin present at the site of collection and thus in the climatic characteristics. However, until now, no mitochondrial functions in relation to stress and apoptotic process were determined. We hypothesized that propolis effects could be due to a direct action on mitochondrial f…

Abstract: Peptides are molecules of paramount importance in several fields, especially in health care and nutrition. They have many beneficial health effects, such as antimicrobial, antiviral, antitumor, neuroactive and immunoactive activity. Several technologies for their production are now available such as chemical synthesis, biosynthesis and chemo-enzymatic peptide synthesis. For combining the advantages of chemical and enzymatic synthesis methods, chemo-enzymatic peptide synthesis has been attracting the interest of res…

Abstract: The aim of the study is to investigate the hepatoprotective activity of Morus alba Linn. leaves extracts against carbon tetrachloride (CCl4) induced hepatotoxicity. Leaves powder of Morus alba was successively extracted with petroleum ether extract (PEE), chloroform extract (CHE), alcoholic extract (ALE) and water extract (AQE) against carbon tetrachloride (CCl4) induced hepatotoxicity using Standard drug Liv-52. Preliminary phytochemical tests were done. The ALE showed presence of alkaloids, flavonoides, carbohydr…

Abstract: The role of histamine in various stages of female reproductive functions is now understood. The anti-implantation activity of various H2 receptor blockers had been established earlier by our laboratory. The present studies were conducted to evaluate the local effects of direct intra-uterine injection of H2 receptor blockers on implantation in albino Wistar rats. The individual administration of ranitidine, famotidine and roxatidine by direct intra-uterine injection on Day 4 of pregnancy in female albino Wistar rats…

Abstract: In Nigeria, general medical doctors objected to physiotherapists assuming the responsibility of being supplementary prescribers. It is unknown if Nigerian specialist doctors (Orthopaedic Surgeons and Neurologists) will have different opinion on supplementary prescription (SP) policy. 71 orthopaedic surgeons and 53 neurologists were recruited using purposive sampling technique. A self-administered questionnaire was used to obtain bio-data, awareness on SP, knowledge about Clinical Management Plan and duration of edu…