Search for Articles:
Journal:
Subject:

Journal Menu

Home

Journal Browser

Vol.16 (2025) Iss. 1
Vol.15 (2024) Iss. 1
Vol.14 (2023) Iss. 1
Vol.13 (2022) Iss. 1
Vol.12 (2021) Iss. 1
Vol.11 (2020) Iss. 1
Vol.10 (2019) Iss. 1
Vol.9 (2018) Iss. 1
Vol.8 (2017) Iss. 1
Vol.7 (2016) Iss. 1
Vol.6 (2015) Iss. 1
Vol.5 (2014) Iss. 1
Vol.4 (2013) Iss. 1
Vol.3 (2012) Iss. 1
Vol.2 (2011) Iss. 1
Vol.1 (2010) Iss. 1

International Journal of Pharmacy and Pharmacology

3 Articles | Volume 12 (2021)
Research Article
F. Pehlivan Karaka *, A. Karaka , H. Co kun and A. Uçar Turker
Abstract: The effects of aqueous extract of flowers from Bellis perennis on anxiety-like behavior and memory in Wistar rats were tested. Vehicle 20 and 60 mg kg -1 B. perennis groups were performed and the animals were tested by open field and elevated plus maze tests for anxiety-like behaviour and Morris water maze test for spatial memory. In the open field, the high dose of B. perennis administrated rats spent more time at the center, showed less mobility and velocity. In the elevated plus maze, the high dose of B. perennis administrated rats spent more time in the open arms, spent less time in the closed arms, were less mobile, were slower and rotated less frequently. In the Morris water maze, the high dose of B. perennis administrated rats spent more of the time to find the platform. In conclusion, B. perennis may produce biphasic effects on both anxiety-like behaviour and learning performance of the rats.[...] Read More.
Keywords: Bellis perennis, common daisy, anxiety, sedative, spatial memory.
Int. J. Pharm. & Pharmacol.   2021, 12(1), 1-6; 
Full text
Views:1295
Download:1398
Research Article
Gada Al Basher, Hossam Ebaid, Jamaan Ajarem and Gasem Abu-Taweel
Abstract: Selenium is an essential element with a narrow margin between beneficial and toxic effects. The learning and sensory motor reflexes-changes were studied after the perinatal exposure of mice to acute toxic doses of sodium selenite. Atomic absorption as well as the behavioral observations were employed. Adult pregnant mice was assigned into three groups: the first group was remained as a control group; the second and the third groups were orally administrated sodium selenite at doses of 1 mg/Kg (1 ppm) and 4 mg/kg (4 ppm) of the diet, respectively started from the 7th day of gestation to the 15th day of birth. Results revealed that body weight gain came significantly lower in pups born to treated mothers than those of the control pups. The appearance of body hair and opening of eyes of the pups from treated mothers were delayed in a dose-dependent manner. Selenite also inhibited the sensory motor reflexes in all elements in a dose dependent manner. The active avoidance test indicated that selenite exposure was associated with learning impairment. Acetylcholine recorded a significant decrease in treated pups. Significant high concentrations of selenium in the brain, liver and kidney was detected, indicating active transfer of selenium from mothers during pregnancy and lactation periods.[...] Read More.
Keywords: Perinatal, sodium selenite, atomic absorption, acetylcholine, active avoidance test, sensory motor reflexes, mice.
Int. J. Pharm. & Pharmacol.   2021, 12(1), 1-6; 
Full text
Views:1298
Download:1355
Research Article
Preeti Jain*, Mahmood Hasan Bhuiyan, Khondker Rufaka Hossain and Sitesh C. Bachar
Abstract: The antibacterial and antioxidant activities of different parts of local seeded banana fruit were investigated in vitro. Dried peels, pulps and seeds of the fruit were extracted with hexane, ethyl acetate and ethanol. Antibacterial property of the extracts was evaluated against four Gram positive and four Gram negative bacteria using disc diffusion technique. Ethyl acetate and ethanol extract of both pulp and peel exhibited antibacterial activity with zone of inhibition ranging from 9 to 24 mm. On the other hand, only ethyl acetate extract of seeds showed antibacterial activity and the zone of inhibition ranged from 8.5 to 10 mm; interestingly, none of the hexane extracts of the three banana parts exhibited zone of inhibition. Antioxidant activity of the extracts was evaluated by total phenolic content determination and 1,1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging assay. Total phenolic content expressed as gallic acid equivalents (GAE) was found to be highest in ethyl acetate extract of banana seed (19.46 mg GAE/g extract) followed by the same extract of banana pulp (15.78 mg GAE/g extract) and peel (11.23 mg GAE/g extract). High free radical scavenging activity was observed with ethyl acetate extracts of banana seed, peel and pulp with an ascorbic acid equivalent antioxidant capacity (AEAC) value of 1238.33, 1011.43 and 588.03 mg AA/ 100 g extract, respectively. Keywords: Seedy banana, antibacterial, antioxidant, phenolic content.[...] Read More.
Keywords: Seedy banana, antibacterial, antioxidant, phenolic content.
Int. J. Pharm. & Pharmacol.   2021, 12(1), 1-6; 
Full text
Views:1324
Download:1323
Subscribe Your Manuscript