International Journal of Pharmacy and Pharmacology (IJPP) is a peer-reviewed, open-access journal that publishes original research papers, critical reviews, short communications and case reports on the latest developments in all areas of pharmacy and pharmacology. [Aims & Scope]

Key Research Areas: A key focus of the journal is research on medicinal plants, natural products, and their pharmacological effects, toxicology, and clinical applications. It also covers the business, regulatory, and professional aspects of pharmacy.

Publisher: Macao Scientific Publishers (MOSP)

Editor-in-Chief: James R. Whiteford | [View the Editorial Board]

Statement: 2010-2026 © MOSP. The journal complies with the Open Access License (CC BY 4.0)

Print ISSN: None | Online ISSN: 2326-7267

Indexing: Under review

Quick Links: Submission Guidelines | Submission System | Contact Editors

3 Articles | Volume 12 (2021)

Research Article

Effects of common daisy (Bellis perennis L.) aqueous extracts on anxiety-like behaviour and spatial memory performance in Wistar albino rats

F. Pehlivan Karaka *, A. Karaka , H. Co kun and A. Uçar Turker

Abstract: The effects of aqueous extract of flowers from Bellis perennis on anxiety-like behavior and memory in Wistar rats were tested. Vehicle 20 and 60 mg kg -1 B. perennis groups were performed and the animals were tested by open field and elevated plus maze tests for anxiety-like behaviour and Morris water maze test for spatial memory. In the open field, the high dose of B. perennis administrated rats spent more time at the center, showed less mobility and velocity. In the elevated plus maze, the high dose of B. perennis administrated rats spent more time in the open arms, spent less time in the closed arms, were less mobile, were slower and rotated less frequently. In the Morris water maze, the high dose of B. perennis administrated rats spent more of the time to find the platform. In conclusion, B. perennis may produce biphasic effects on both anxiety-like behaviour and learning performance of the rats.[...] Read More.

Keywords: Bellis perennis, common daisy, anxiety, sedative, spatial memory.

Int. J. Pharm. & Pharmacol. 2021, 12(1), 1-6;

Full text

Download：1398

Research Article

Impairment of active avoidance learning and sensory motor reflexes in mice offspring induced by perinatal acute toxic exposure to selenium

Gada Al Basher, Hossam Ebaid, Jamaan Ajarem and Gasem Abu-Taweel

Abstract: Selenium is an essential element with a narrow margin between beneficial and toxic effects. The learning and sensory motor reflexes-changes were studied after the perinatal exposure of mice to acute toxic doses of sodium selenite. Atomic absorption as well as the behavioral observations were employed. Adult pregnant mice was assigned into three groups: the first group was remained as a control group; the second and the third groups were orally administrated sodium selenite at doses of 1 mg/Kg (1 ppm) and 4 mg/kg (4 ppm) of the diet, respectively started from the 7th day of gestation to the 15th day of birth. Results revealed that body weight gain came significantly lower in pups born to treated mothers than those of the control pups. The appearance of body hair and opening of eyes of the pups from treated mothers were delayed in a dose-dependent manner. Selenite also inhibited the sensory motor reflexes in all elements in a dose dependent manner. The active avoidance test indicated that selenite exposure was associated with learning impairment. Acetylcholine recorded a significant decrease in treated pups. Significant high concentrations of selenium in the brain, liver and kidney was detected, indicating active transfer of selenium from mothers during pregnancy and lactation periods.[...] Read More.

Keywords: Perinatal, sodium selenite, atomic absorption, acetylcholine, active avoidance test, sensory motor reflexes, mice.

Int. J. Pharm. & Pharmacol. 2021, 12(1), 1-6;

Full text

Download：1355

Research Article

Antibacterial and antioxidant activities of local seeded banana fruits

Preeti Jain*, Mahmood Hasan Bhuiyan, Khondker Rufaka Hossain and Sitesh C. Bachar

Abstract: The antibacterial and antioxidant activities of different parts of local seeded banana fruit were investigated in vitro. Dried peels, pulps and seeds of the fruit were extracted with hexane, ethyl acetate and ethanol. Antibacterial property of the extracts was evaluated against four Gram positive and four Gram negative bacteria using disc diffusion technique. Ethyl acetate and ethanol extract of both pulp and peel exhibited antibacterial activity with zone of inhibition ranging from 9 to 24 mm. On the other hand, only ethyl acetate extract of seeds showed antibacterial activity and the zone of inhibition ranged from 8.5 to 10 mm; interestingly, none of the hexane extracts of the three banana parts exhibited zone of inhibition. Antioxidant activity of the extracts was evaluated by total phenolic content determination and 1,1-diphenyl-2- picrylhydrazyl (DPPH) free radical scavenging assay. Total phenolic content expressed as gallic acid equivalents (GAE) was found to be highest in ethyl acetate extract of banana seed (19.46 mg GAE/g extract) followed by the same extract of banana pulp (15.78 mg GAE/g extract) and peel (11.23 mg GAE/g extract). High free radical scavenging activity was observed with ethyl acetate extracts of banana seed, peel and pulp with an ascorbic acid equivalent antioxidant capacity (AEAC) value of 1238.33, 1011.43 and 588.03 mg AA/ 100 g extract, respectively. Keywords: Seedy banana, antibacterial, antioxidant, phenolic content.[...] Read More.

Keywords: Seedy banana, antibacterial, antioxidant, phenolic content.

Int. J. Pharm. & Pharmacol. 2021, 12(1), 1-6;

Full text

Download：1323