International Journal of Pharmacy and Pharmacology

Abstract: Increase in the prevalence of diabetes worldwide and it becoming an epidemic has resulted in a clinical research shift to the management of diabetes mellitus globally. The study aimed to investigate the socio-demographic differences among diabetes patients with infection incidence. The study was conducted in an urban, governmental hospital in Penang Malaysia. The records of patients, more than and equal to age 18 years, who were admitted with diabetes mellitus between January 1, 2008 and December 31, 2010 were revi…

Abstract: The activity of fractions derived from hydroalcoholic extract of Dodonaea viscosa leaves against Candida albicans (Cl. I. 4043) was evaluated. The hydroalcoholic extract was sequentially fractionated to give n-hexane, dichloromethane, ethylacetate and n-butanol fractions that were subjected to qualitative phytochemical analyses. Disk diffusion assay was used in preliminary anticandidal screening with clotrimazole and chloroform serving as positive and negative controls, respectively. Optimized solvent systems were…

Abstract: Rosmarinic acid from the plants quenched superoxide radicals from xanthine oxidase and inhibited cyclooxygenase I and II enzymes. Antioxidants have essential effect on diabetes. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Wistar male rat (n=40) were allocated into three groups, control group (n=10), rosmarinic acid (Ro) group that received 5 mg/rat (gavage) (n=10) and diabetic group that received 55 mg/kg (I…

Abstract: This study describes the development and validation of an isocratic HPLC method for the stability of gliclazide assay in the presence of metformin hydrochloride (MET) in pharmaceutical dosage forms using ion pair - reversed phase liquid chromatographic technique. The ion pairing agent used in this study is tetrabutyl ammonium hydrogen sulphate (TBHS). The TBHS 0.030 molar solution in water was adjusted to pH 6.0 with 1 N sodium hydroxide solution and was used as buffer. The composition of the buffer and acetonitril…

Abstract: International Journal of Pharmacy and Pharmacology ISSN 2326-7267 Vol. 11 (5), pp. 001-004, May, 2022. © International Scholars Journals Full Length Research Paper Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients Hassan Ahmadvand1*, Amir Majdaldin Amir Javanbakht2 and Hussein Matooriyan Pour2 1Department of Clinical Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran. 2Department of Dermatology, School of Medic…

Abstract: This study concerns the discovery of the effectiveness of an alcoholic total extract of the aerial parts of the plant Anisotes trisulcus (Forssk.) Vahl family Acanthaceae and its active constituent peganine as a new means for suppression of tobacco intake and as a suppression to appetite (as anorexigenic). The treatment of Wistar rats with the total alcoholic extract in doses of 600 mg/100 mL drinking water decreased oral nicotine intake by 87.7% and food intake by 84.9%. The active constituent peganine in doses of…

Abstract: The use of L-carnitine is very popular in recent years, but because of the lack of clinical trials, they are still sufficiently descriptive, and thus remain a mystery. However, a very common complication in hemodialysis patients is caused by a decrease in the serious incidence put forward by recent studies. This study aims to show if there are common reduced complications in patients using L-carnitine. All the patients treated in our center, and who were included in this study and in each session (three sessions pe…

Abstract: Azadirachta indica (neem) is attributed to have many ethnopharmacological properties and has been postulated to have a significant effect on CD4 counts in HIV/AIDS subjects, however, the precise anti-retroviral mechanism is not yet known. In this study, a hydroacetone extract of A. indica leaves was investigated for its anti-retroviral and immunomodulatory potentials. The effect of the neem leaf extract on acute HIV infectivity and fusion was measured by the syncytia formation assay on HIV-1-infected C8166 CD4+ cel…

Abstract: Dacarbazine (DTIC) loaded or blank methoxy poly (ethylene glycol)-poly (lactide) (MPEG-PLA) nanoparticles (NPs) were prepared by modified w/o/w double emulsion-solvent evaporation method through ultrasonic processor without any additional additives. The hemolytic test and cytotoxicity test of blank MPEG-PLA NPs demonstrated that the obtained drug delivery system is safety. Its particle size distribution, morphology, drug loading, drug release profile and anticancer activity in vitro were studied in detail. The smal…