International Journal of Pharmacy and Pharmacology

Abstract: The present study investigated expressions and functions of glucocorticoid receptor (GR) and nuclear factor kappa B (NF-kB) in rat livers after traumatic hemorrhagic shock. The rat model of bilateral femur fracture accompanied with traumatic hemorrhagic shock was established. 96 male Wistar rats were randomly divided into normal control group (n = 6), traumatic shock group (n = 30), GR blocking group (n = 30) and NF-kB inhibiting group (n = 30). 10 g/L of Ru486 (Mifepristone) was given via intramuscular injection 1…

Abstract: Aloe vera is a well known medicinal plant contents with over 75 different ingredients, anthraquinones, saponins, and sterols. Recent studies showed that it is a potent hypolipedimic, hypoglycemic and antioxidant. In present study we investigated the dose dependent effect of aloe vera gel on repolarization state of myocardium, heart rate, QRS complex and QT interval using electrocardiograph in albino rats. A total of 24 male albino rats were divided into four groups, one control and three experimental. An aqueous so…

Abstract: The colonial morphology, the cells and the spores of a bacterium had been observed that could produce an anti-Mycobacterium tuberculosis antibiotic. By physiological and biochemical characteristics and by 16S rDNA analysis, this bacterium was identified as Bacillus subtilis.[...]

Abstract: We assessed the antibiotic production potentials of ten putative Streptomyces strains isolated from the Nahoon beach and their antibacterial activities against a wide range of bacteria including reference strains, environmental strains and clinical isolates. The minimum inhibitory concentrations (MICs) of the crude ethyl acetate extracts ranged from 0.039 to 10 mg/mL and the least minimum bactericidal concentration (MBC) demonstrated was 0.625 mg/mL against a reference strain Staphylococcus aureus ATCC 6538. Time k…

Abstract: This study was carried out to determine the influence of a 6-week pre- season exercise programme including aerobic and anaerobic loads on xanthine oxidase and uric acid levels of male athletes. Fifty voluntary subjects ( the average age is 23 ± 5) participated in this study as study a group. The control group included 30 healthy resting male volunteers with the average age of 23 ± 6. For 6 weeks, the athletes participated in pre-season training programme private to their sports branches 5 times a week. The programm…

Abstract: A sensitive and rapid high performance liquid chromatography method was developed and validated for the determination of aerodynamic characteristics of the emitted dose of budesonide from different inhaler dosage forms. The mobile phase consisted of a mixture of acetonitrile and 10 mM ammonium acetate (63:37% v/v) adjusted to pH5 with orthophosphoric acid. The HPLC analysis was performed at a flow rate of 1 mL/min using a C18 Zorbax Eclipse Plus column (250 x 4.6 mm, 5u) and an UV detection wavelength of 254 nm was…

Abstract: Piper betel Linn. leaves were evaluated for its antihistaminic activity, commonly known as Pan, Vidyache Pan or Tamboli. P. betel has a long history of use in India being applied in multiple therapeutic activities like antibacterial, treating eczema, lymphangitis, asthma, treating rheumatism. So selected, the plant P. betel is effective in histaminic activity related diseases, but antihistaminic activity of P. betel is still not scientifically investigated. In the present study, the pharmacological evaluation of et…

Abstract: The present work studied the effect of metalaxyl on the structure and function of the kidney of albino mice. The work extends to study the possible role played by the aqueous extract of Ginger (Zingiber officinale) in minimizing the toxicity of metalaxyl. Animals were divided into 4 groups. Group 1: given metalaxyl at a dose level of 1/10 LD50 for 4 weeks, Group 2: given metalaxyl and ginger, Group 3: given ginger and Group 4: controls. Kidney cortex of metalaxyl-treated mice showed many histopathological alteratio…

Abstract: Crude extracts of four actinomycetes species belonging to Actinoplane [NB 034], Streptomyces [TR 007] and Actinopolyspora [NB 069 and TR 008] genera were screened for antibacterial activities against a wide range of bacterial strains. The extracts showed antibacterial activities against both Gram-negative and Gram-positive test bacteria with zones of inhibition ranging between 2 and 27 mm (NB 034); 9 and 15 mm (TR 007); 8 and13 (NB 069) and 2 and 12 mm (NB 069) . The minimum inhibitory concentration (MIC) of the ex…

Abstract: We report antimicrobial potential of extracts of roots of Triclisia subcordata and whole plant of Heinsia crinita used as components of various herbal portions in ethnomedine in South West Nigeria to treat acute urinogenital infections and infertility. Methanol and hexane extracts of each plant were obtained by maceration and tested for antimicrobial activity using agar diffusion and microbroth dilution techniques. The extracts were tested against strains of Staphylococcus aureus, Escherichia coli, Bacillus subtili…

Abstract: Chrysophyllum cainito is a plant recognized by the traditional healers of Aboudé-Mandéké, a village in the Department of Agboville (Côte-d’Ivoire), as having antidiabetic properties. The aim of this study is to evaluate, experimentally, the effect of an aqueous decoction of the plant’s leaves that we called C. cainito, on rabbits induced with alloxane, a diabetogenic product. Different graded doses of this herbal medicine were applied on postprandial blood sugar levels of diabetic rabbits. At doses of 10 g/l, C. ca…

Abstract: The ethanolic extracts of Bidens pilosa and Ocimum suave were evaluated for their wound healing potential on excision wound models in Wistar albino rats. A total of nine (n=9) rats per group were used to assess the wound healing potential of the extracts. There were four groups of animals treated topically twice a day with either of the following: O. suave, B. pilosa , neomycin sulfate or distilled water. The rate of wound contraction, epithelialization, and complete healing were assessed over the experimental peri…

Abstract: The aim of this study was to determine the estrogenic activity of Nigella sativa (NS) by vaginal cornification assay using an ovariectomized rat model. Forty ovariectomized Sprague Dawley rats, weighting 250 to 350 g were used in the study. N. sativa powders were administered to ovariectomized rats for 21 consecutive days at dosages of 300, 600 and 1200 mg/kg respectively, and were compared with each of daily treatment with 0.2 mg/kg conjugated Equine estrogen as positive control or distilled water as negative cont…

Abstract: A new simple and rapid high performance liquid chromatography (HPLC) method was developed for the determination of cetirizine hydrochloride (CTZ) in tablets using CLC-ODS reverse phase column (4.6 × 250 mm, 5 µm). Salicylic acid was used as internal standard. A mixture of methanol and water of 70:30 with pH 4 (adjusted with o-phosphoric acid) was used as mobile phase. The eluents were detected at 231 nm. The coefficient of determination of calibration curve for CTZ and salicylic acid in mobile phase were 0.9898 and…

Abstract: The effect of aqueous leaf and berry extracts of Phytolacca dioica administered at 50, 100 and 200 mg/kg body weight for 14 days was investigated on haematology and weight parameters of Wistar rats. The extracts at all doses had no significant effect on the red blood cells (RBC), haemoglobin (HB), parked cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) when compared with the animals in the control group. In contrast, the extra…