International Journal of Pharmacy and Pharmacology

Abstract: The adhesion of Escherichia coli to uroepithelium can be altered by the interaction between specific carbohydrate molecules and the receptors on the bacterial surface. Mannose is one of the most potent inhibitors among carbohydrates. Aloe saponaria, currently used as a dietary supplement, contains polymannanes as main components. This work was designed to evaluate the mannose oligosaccharide metabolites excretion after oral intake of Aloe saponaria pulp in order to estimate its potential utility in preventing urina…

Abstract: Rational drug use is consequential to effective management of chronic conditions such as hypertension. This study was carried out to compare the quality of prescription in patients attending the outpatient clinics of a tertiary hospital in Nigeria against standard values and to compare study findings with similar studies carried out in other parts of the country. One thousand nine hundred and seventy-two case notes were reviewed following each clinic. Quality of prescription was assessed using WHO prescribing indic…

Abstract: Experimental strategies for cancer treatment have been developed to enhance cell-mediated immunity; some have generated promising results. Several heat shock proteins (HSP) derived from tumorgenic cells have been found capable of effectively initiating specific anti tumor immunity. The sympathetic nervous system innervates primary lymphoid organs and also influences T-lymphocyte maturation. This study had two main objectives: first to evaluate the effects of HSP-70-rich tumor lysate as an experimental tumor treatme…

Abstract: The root extract of Echinops kebericho is used traditionally for the treatment of diarrhea. This study describes the anti-diarrheal and anti-spasmodic activities of the aqueous root extract of E. kebericho. The effect of extract in rodents on castor oil-induced intestinal transit, diarrhea and enteropooling was evaluated at doses of 100, 200 and 400 mg/kg body weight. The effects of extract on acetylcholine-induced guinea pig ileum contractions were also evaluated. In the castor oil induced intestinal transit test…

Abstract: Drug combinations represent current treatment strategies in the management of malaria. Nitric oxide (NO) has been proposed to inhibit Plasmodium growth due to its parasite-scavenging activity thus the effects of various combinations of an NO inducer - anthraquinone (25-100 mg/kg, ANT), an NO donor - sodium nitroprusside (0.5 mg/kg, SNP) and NO inhibitor -nitro-L-arginine methyl ester (40 mg/kg, L-NAME) and their combination drugs were evaluated using the antimalarial curative model in Plasmodium berghei-infected mi…

Abstract: Loratadine is a second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. The present work was aimed to develop of Loratadine using HPMC E15 LV PREMIUM as film forming polymer, glycerin as a plasticizer and tween 80 as a surfactant. The strips were evaluated for thickness, tensile strength, % elongation, disintegration time and in vitro drug release. A trial and error approach was used in present study for optimization. Oral strip containing HPMC E15 LV PREMIUM (19…

Abstract: Malaria is one of the most serious health problems worldwide and treatment has been compromised by drug resistance. Consequently, efforts are directed towards discovery of novel agents including from medicinal plants. The present study was aimed to evaluate the suppressive, curative and prophylactic activity of hydroalcoholic leaf extract of Calpurnia aurea in mice infected with chloroquine sensitive Plasmodium berghei (1x107parasites/mouse). The extract (15, 30 and 60 mg/kg), chloroquine (5 mg/kg) and distilled wa…