Fully benchmarking against MDPI's standardized publishing process, a closed-loop workflow is established covering initial screening and preliminary review, peer review, revision and re-review, final review and acceptance, typesetting and publication, and archiving and public disclosure, with clear time limits and standards for each stage, so as to improve publication efficiency and standardization.
Initial Screening and Format Review
Upon submission, the editorial staff conduct the initial screening without delay, checking whether the manuscript falls within the journal's scope, whether it has been submitted to multiple journals simultaneously, whether the format is compliant, and whether the supplementary materials are complete. The manuscript structure is strictly reviewed and must follow the IMRAD structured abstract standard, comprising the four core modules of research background, research methods, key results, and conclusions, free of redundant or irrelevant content. Manuscripts that fail the initial screening are returned directly, with the authors clearly informed of the directions for revision or the reasons for rejection, so as to eliminate ineffective review assignments.
Key points checked during initial screening: disciplinary fit of the manuscript, originality, format compliance, completeness of funding and ethics statements, clarity of figures and tables, and the standardization of references. Manuscripts that are empty in content, poorly formatted, or deviating from the journal's positioning are rejected.
Academic Preliminary Review
Manuscripts passing the initial screening are subject to academic preliminary review by the corresponding Section Editor, who focuses on evaluating the novelty of the research, the value of the topic, the feasibility of the study, and the scientific soundness of the content, as well as verifying the authors' research qualifications and foundation, and screening for obvious academic deficiencies. Manuscripts that pass the preliminary review proceed to peer review; those with minor deficiencies that can be remedied are returned to the authors with a deadline for revision before re-review; manuscripts without academic value or with major defects are rejected directly at the preliminary review stage.
Peer Review Mechanism
A double-blind peer review system is adopted, with strict measures to avoid conflicts of interest and ensure fairness and impartiality. All manuscripts sent for review are evaluated by at least two or more authoritative reviewers in the same field; for particularly difficult manuscripts and manuscripts of high novelty, one or two additional external reviewers are engaged for verification.
Reviewers must issue independent review opinions, clearly indicating one of four conclusions — accept, accept after revision, revise and re-review, or reject — and detailing the basis of the review, the strengths and weaknesses of the manuscript, and specific revision suggestions. Editorial staff follow up on the review progress throughout, collect review reports in a timely manner, and coordinate communication between authors and reviewers for questions and clarification.
Where multiple review opinions diverge, the Executive Editor-in-Chief organizes the Academic Editors to conduct a joint re-assessment and issue the final review recommendation, ensuring that review results are objective and fair.
Manuscript Revision and Re-review
For manuscripts requiring revision, authors are notified of a unified revision deadline; the revision period for regular manuscripts does not exceed ten working days. Authors must respond to the reviewers' comments point by point and submit a response letter, the revised manuscript, and the original supplementary materials. Upon completion of revision, the manuscript is returned to the original reviewers for re-review to verify that the revisions have been implemented and the issues effectively addressed. Manuscripts requiring extensive additional experiments or substantial restructuring of core content are rejected; after completing a full revision, the authors may resubmit, and the resubmission will be assigned a new manuscript number with the review process restarted from the beginning.
Final Review and Acceptance
Manuscripts that pass the re-review undergo tiered final review by the Executive Editor-in-Chief and the Editor-in-Chief, who comprehensively re-examine the academic quality, completeness of revisions, ethical compliance, and authenticity of data. Once confirmed to be free of issues, the manuscript is accepted. Manuscripts failing the final review are given explicit reasons for rejection; the result of the final-review rejection is final and is not subject to further appeal or re-examination.
Typesetting, Proofreading, and Publication
Accepted manuscripts enter the production stage, where a dedicated team completes language polishing, formatting and typesetting, figure and table optimization, XML and PDF conversion, and a second round of proofreading, eliminating typographical errors, formatting problems, and distorted figures or tables. After proofreading, the manuscript is submitted to the authors for final confirmation of the version of record; once no objections remain, it is formally published online or in print, with archiving, copyright registration, and database indexing notification completed at the same time.