International Journal of Pharmacy and Pharmacology

Abstract: This paper evaluated anti-ulcer, anti-secretory and anti-helicobacter pylori effects of folkloric medicinal plant, Fumaria vaillantii L, in rats. Different toxic agents; ethanol (80%), NaOH (0.2 mol/L), NaCl (25%) and indomethacin (30 mg/kg, body weight) were used to produce acute gastric ulceration in rats. Anti-secretory studies were undertaken by using pylorus-ligation, Shay rat technique. F. vaillantii L aqueous extract (Aq-FV) was used in three doses (100, 200 and 300 mg/kg bodyweight). Aq-FV was further teste…

Abstract: Hydroquinone, a dihydroxylated benzene derivative is used therapeutically as a topical agent for the treatment of certain skin conditions. Ten (10) cosmetic creams containing hydroquinone were randomly sampled based on consumer demand from the open market in Jos, Plateau State. The labels on the packages noticeably did not indicate the levels of hydroquinone present. The creams were subjected to colour and chromatographic test for identification, as well as assay by UV spectrophotometry. All ten (10) creams sampled…

Abstract: Clopidogrel resistance plays a key role in ischemic recurrence after Percutaneous coronary intervention (PCI). The cytochrome P450 (CYP)–dependent conversion of Clopidogrel to its active metabolite may contribute to the variability in antiplatelet effect of Clopidogrel. To evaluate the response to 600 mg Clopidogrel loading dose versus 300 mg loading dose in patients undergo PCI. A total of 51 patients categorized to two groups: Group I consisted of 11 males (64.7%) and 6 females (35.3%) received 300 mg loading doe…

Abstract: Phytochermical screening and antimicrobial activity of the aqueous and ethanolic extract of the stem-bark of Datura stramonium was carried out. The extraction with the two solvents (water and ethanol) was carried out at room temperature. The phytochemical investigations include saponins, tannins, steroids, alkaloids, flavonoids, phenols and glycosides. The antimicrobial activity was investigation on Staphylococcus aureus, Salmonella typhi, Shigella spp, Eschericia coli, Klebsiella pneumonia and Neisseria gonorrhea…

Abstract: Medicinal plants are used in the treatment and management of most diseases worldwide. One of such diseases is diabetes. It is a metabolic disorder characterized by lack of insulin or inadequate supply of insulin. It affects one quarter of the world’s population as reported by World Health Organization. ANACARDIUM OCCIDENTALE parts are used in the management of diabetes hence the need to study its effect on the biochemical and haematological parameters. The ethanolic extract of A. OCCIDENTALE leaves at 2000, 4000 an…

Abstract: Annona squamosa (L.) leaves were extracted with ethanol using percolation method and the extract obtained was partitioned in chloroform and distilled water at a ratio of 1:1 using 30ml volume. The extract and fractions were tested for antibacterial activity against clinical respiratory tract isolates of Klebsiella pneumoniae, Proteus species, Pseudomonas species, Staphylococcus aureus, Streptococcus pneumoniae and α-haemolytic Streptococci using disc diffusion and micro-broth dilution techniques. The extract and fr…

Abstract: The effects of B success, a herbal supplement on the reproductive organs of male albino rats were investigated. The herbal product was given orally to three dose groups of five male rats each, namely 315, 630, 945mg/kg/body weight (b.w) for 90 days and were fed AD LIBITUM with rat chow, the control group received only deionised water. Afterwards, the rats were bled-sacrificed. The testes were excised and weighed, and their protein and DNA determined. Also epididymal sperm count (ESC), testosterone and lead in blood…

Abstract: Out of the 1114 strains belonging to 29 genera and 105 species of microbes (molds, yeasts and bacteria) isolated from different sources [clinical cases, environment (water, air, soil, droppings of lizards and birds), food and healthy animals], 38.2% were sensitive to lemongrass oil discs containing 50 µg oil/disc. All molds, yeasts, Lactobacillus acidophilus, Morganella morganii, most of the Bacillus spp. strains (84.3%), aeromonads (78%), Edwardsiella spp. (73.9%), 53.6% pseudomonads, 53.1% streptococci and 50% of…

Abstract: Tuberculosis is a chronic infectious disease caused by etiologic agent Mycobacterium tuberculosis. “It has been reported that rates of incidence is increasing and each year around 8.9-9.9 million new cases are detected”. The current TB therapy presents several problems such as long-term therapy, drug resistance, no-compliance to therapy and few therapeutic sources to treat the disease. The discovery of new drugs safer and more efficient is urgent. The molecular modification is an important tool that allows discover…

Abstract: Multiple tumor samples were collected from 32 bovines (BOS TAURUS TAURUS x BOS TAURUS INDICUS), of both sexes, bearers of pedunculated cutaneous flat and/or mixed papillomatosis. The samples were fixed in 10% buffered neutral formalin solution and submitted to histothecnique by inclusion in paraffin for hystopatologic analysis and used in the preparation of an autogenous inactivated vaccine for treatment. The objective of the present work is to show the clinical pathological finding and the classic cytomorphologic…

Abstract: Oral mucosal tropism also has been documented in humans, canines, primates and wild mammals. The effectiveness of combined therapy has shown greater success in the treatment of cutaneous papillomatosis and oral mucosal lesions. Autogenous vaccine, homeopathy and immunotherapy have been employed in the treatment of the cutaneous lesions and oral mucosal papillomatosis in different species. In the present study, we reported about papillomavirus clinical infection in canines. Based in the clinical analysis, the surgic…

Abstract: Reports have been made that the ingestion of unripe Blighia sapida (ackee) fruits may be responsible for poisoning resulting in a substantial number of unexplained deaths. This study was carried out to investigate the effect of Blighia unijugata, a sister specie of Blighia sapida on the histology of the liver and kidney. Twenty male rats were divided randomly into four groups of five rats each. Group 1, the control received daily oral dose of distilled water. Group 2, 3 and 4 were administered 424 mg/kg, 849 mg/kg…

Abstract: The research work focused on the effect of aqueous extract of the seed of Persea americana (Avocado) on the cholesterol, triglycerides, low density lipoproteins levels in the blood of rabbits. A total of thirty rabbits were used of ten in each of groups A, B and C. Group A served as control. The test groups (B and C) were fed ad libitum with starter finish before and after administration of the extracts (w/w) by intubation. Two concentrations of the extracts of 100mg/kg body weight and 200mg/kg bodyweight were admi…

Abstract: One of the main factors limiting the use of cyanoacrylate is its high cost. Despite the relatively small amount of literature on this subject, we have been able to demonstrate their safe use in skin closure. Objective: To compare the cyanoacrylate adhesive with the usual techniques of skin closure with surgical thread, assessing its final aesthetic effect and possible complications. Materials And Methods: We studied 126 patients from the Department of General Surgery, Hospital Regional de Mato Grosso do Sul in the…

Abstract: This is a prospective pre-post study which was carried out to assess the impact of a community pharmacist-based diabetes management program on clinical outcomes measures. Forty seven outpatients from the Government polyclinic were initially enrolled for this study but only 30 stayed on till the end of the program which was for duration of 3 months. Subjects were followed-up on 4 visits, whereby the community pharmacist provided a structured, standardized diabetes education program which involved counseling and educ…