International Journal of Pharmacy and Pharmacology

Abstract: CITRUS AURANTIFOLIA is used in African folk medicine for the management of hypertension. In order to provide a scientific basis for this use, we studied the effects of an aqueous extract of CITRUS AURANTIFOLIA (Ecita) on arterial blood pressure and on isolated heart and aorta activities. Rabbits were used for the study on the arterial blood pressure using a Ludwig manometer. Albino Wistar rats were used for the studies regarding the isolated heart and aorta activities using isolated organ bath systems. Ecita (4mg/k…

Abstract: Psychiatric diseases have become a public health problem owing to their increased prevalence. An option for their treatment is psychoactive medications, which are associated with multiple adverse effects. The purpose of this study was to determine the pharmacoepidemiology of psychoactive medication and the prevalence of psychiatric disease in adult patients seen at the Psychiatry Department at Durango General Hospital. Clinical histories of the patients were reviewed for patients over 18 years of age that were seen…

Abstract: A series of new mixed ligand complexes of Co(II) and Cu(II) with thiosemicarbazones/semicarbazone {(±)-5-isopropenyl-2-methylcyclohex-2-enthiosemicarbazone (IPMCHTSC, L1H), 1,7,7-trimethylbicyclo[2,2,1]heptanethiosemicarbazone (TBHTSC, L2H) and 1,7,7-trimethylbicyclo [2,2,1]heptanesemicarbazone (TBHSC, L3H)} and amino acids {glycine (A1H) or DL-alanine (A2H)} have been synthesized by the reaction of metal dichloride with ligands IPMCHTSC, TBHSC or TBHTSC and A1H or A2H in a 1:1:1 molar ratio in refluxing ethanol. T…

Abstract: The phytochemical analysis, elemental analysis, antimicrobial activities and the minimum inhibitory concentration (MIC) of aqueous and ethanolic extracts of the leaves of Cassia arereh Del. were carried out. Phytochemical investigation revealed the presence of several bioactive compounds such as alkaloids, flavonoids, anthraquinones, saponins, glycosides, tannins, carbohydrates and terpenes. Elemental analysis revealed the presence of calcium (Ca), phosphorus (P), Manganese (Mg), Manganese (Mn), Iron (Fe), Copper (…

Abstract: A study was conducted to evaluate the nutritional potentials of three commonly available, aquatic weeds namely, lemna (Lemna minor), water hyacinth (Eichhornia crassipes Crassipes ) and azolla (Azolla pinnata) for ascertaining their suitability as complementary fish feed with the aim to reduce the cost of traditional feeds. Three isonitrogenous (30% crude protein approximately) and isocaloric (4.0 kcal g−1 approximately) diets were formulated including lemna, water hyacinth and azolla as principal ingredient. Three…

Abstract: Some adverse drug reactions are due to hypersensitivity reactions. Drug allergy related errors in a handwritten treatment compared with those in an electronic prescribing system, characteristics of reported allergies and economic impact were analyzed. Prospective, observational study was carried out in two phases. 1st Phase (manual prescriptions), errors due to drug allergy were detected when pharmacists registered allergies and then warned the physician. 2nd Phase (electronic prescription) physicians registered al…

Abstract: The leaf of the African Mistletoe (Loranthus micranthus Linn) parasitic on Kola acuminata in Nsukka, Eastern Nigeria was studied. The crude petroleum ether extract (CPE) and ethanol extract of the CPE residue (EER) of Loranthus micranthus Linn were subjected to phytochemical and antimicrobial evaluation. Results of the phytochemical screening showed that EER had proteins, carbohydrates and reducing sugars while CPE had none of these metabolites. Flavonoids was absent, while tannins, steroids, saponins and terpenes…

Abstract: A new, rapid, sensitive and selective method for the spectrophotometric determination of xipamide in pure and dosage forms is proposed. The method is based on the reaction of xipamide with Fe(III), Cu(II), La(III), UO2(II), Th(IV) and ZrO(II) ions to form stable colored complexes. The formed complexes have maximum absorbance at 500, 390, 335, 445, 325 and 333 nm for Fe(III), Cu(II), La(III), UO2(II), Th(IV) and ZrO(II), respectively. Optimum conditions for determination, stoichometry and stability of the formed com…

Abstract: We have evaluated the phytochemical and bioactive nature of the leaves of Mallotus peltatus (Geist.) Muell. Arg. var acuminatus and Alstonia macrophylla Wall ex A. DC, the two major ethno medicines of the Onge, Nicobarese and other tribes of Andaman and Nicobar Islands, on the Bay of Bengal, India. Three major compounds were isolated from the polar fractions of the methanol extracts of A. macrophylla leaf namely β-sitosterol (fraction A), ursolic acid (fraction B) and β-sitosterol β-D-glucoside (fraction C), along…

Abstract: Ashwagandha, Tulsi, Mulethi, Awala, Shatavari, Gokharu, Arjun, Giloy, Safed musli, Kalimirchi, Haldi, Jaiphal was used as an active ingredients and aqueous extract of Stevia rebaudiana as natural sweetener with nutraceutical in health dinks. The product was developed by treating concentrates of each crude drug with purified water. TLC profile, HPTLC method development and validation were carried out using Gallic acid as a standard. A new simple, sensitive, selective, precise and robust HPTLC method for analysis of…

Abstract: Aqueous leaf extract of Cajanus cajan is consumed by pregnant women in our locality. However, its effect on pregnancy has not been studied. C. cajan is known to contain genistein and diadzein which are potent phytoestrogens. We studied the effect of aqueous leaf extract of C. cajan on litter size and serum progesterone in pregnant rats. Oral administration of C. cajan on timed-pregnant rats increased litter size from 7.2 ± 1.1 in the control gorup to 10.1 ± 1.5 (p < 0.01) and 10.6 ± 0.8 (p < 0.003) in 100 and 200 m…

Abstract: Randia dumetorum Lamk., a plant widely used in the traditional medicinal systems of India, has been reported to possess antiviral, antibacterial and anti-inflammatory activities. In present study, the attempt was made to screen immunomodulatory activity of methanol extract and its petroleum ether, chloroform, ethyl acetate and methanol fraction of fruits of R. dumetorum. The effects of R. dumetorum on cell mediated and humoral components of the immune system in mice were observed. Administration of chloroform fract…

Abstract: The antioxidant activity of aqueous extract of leaves of Ageratum conyzoides (AC) in the serum of male diabetic rats was evaluated using Ferric Reducing Antioxidant Power (FRAP) assays, by determination of malonadehydes, lipid hydroperoxydes and protein thiol groups. The plant extract was tested at doses of 100, 200 and 300 mg/kg on diabetic rats during three weeks of treatment; glibenclamide (10 mg/kg) was used as positive control. Glycaemia of diabetic rats was also determined, at the beginning and at the end of…

Abstract: The plant Moringa concanensis Nimmo is a tree belongs to family Moringaceae locally known as Kattumurungai by tribal peoples of Nilgiris hill region in Tamilnadu. In view of its medicinal importance and taxonomic confusion, pharmacognostic studies, microscopical structure, morphological characters, chemical analysis and numerical values in epidermal study were carried out to supplement the necessary information for the systematic identification and authentication of this plant, as per WHO guidelines. Pharmacognosti…

Abstract: Great efforts are ongoing in understanding and management of diabetes, the disease and disease-related complications are increasingly unabated. In spite of the presence of known antidiabetic medicine in the pharmaceutical market, remedies from medicinal plants are used with success to treat this disease. In the present investigation an attempt is made to study the beneficial effects of Basella rubra in streptozotocin-induced diabetic rats and validate its traditional claim. The diabetes-induced rats were fed with B…