MOSP - Macao Scientific Publishers

文章

Sex based pharmacological treatment in patients with metabolic syndrome: Findings from the Isfahan healthy heart program

Mojgan Gharipour*, Roya Kelishadi, Nafiseh Toghianifar, Mahsa Mackie, Mehrdad Yazdani, Fatemeh Noori and Nizal Sarrafzadegan

Abstract: Pharmacological therapy is a critical step in the management of individuals with the metabolic syndrome (MetS) when lifestyle modifications cannot achieve the therapeutic goals. However, it has been well- documented that there is no single best therapy other than weight loss, and that treatment should be targeted at individual components of the MetS. The objective of this study was to investigate the treatment of individual components of the MetS in a population-based sample of individuals with clustering MetS components. In a cross-sectional population-based survey, we studied a randomly collected sample of men and women who had participated in the baseline survey of a community-based program in three Central Iranian counties in 2000 to 2001. Demographic data, medical status, and drug history were obtained by questionnaire. We evaluated the association between clustering of the MetS components and pharmacological treatment of cardiovascular risk factors. The most common pharmacologic agents prescribed for individuals with the MetS were beta-blockers (72.8%), followed by lipid-lowering agents (36%) with no significant gender difference. A high level of compliance with drug treatment was noted. Further research is warranted to understand the compliance behavior of patients with the MetS.[...] Read More.

Keywords: Iran, metabolic syndrome, pharmacological treatment, compliance.

Full text

Download：942

文章

Element content analysis of plants of genus Ficus using atomic absorption spectrometer

Kiran Yasmin Khan*, Mir Ajab Khan, Rabia Niamat, Mamoona Munir, Hina Fazal, Paras Mazari, Nighat Seema, Tasmia Bashir, Ammarah Kanwal and Sidra Nisar Ahmed

Abstract: Ficus species have wide distribution and uses worldwide traditionally as medicine, vegetable, food, fodder and fuel wood etc. The flame atomic absorption spectrophotometer was employed for the estimation, conducted on four plant parts (leaves, bark, aerial roots and fruits) of 12 samples of eight medicinally important species of Ficus and nine samples of wild edible fruits of genus Ficus, collected from different locations within Pakistan. The results of the present study provide justification for the usage of these fruits in daily diet for nutrition as well as for medicinal usage and medicinal plants in the treatment of different diseases. The metal contents in the samples were found at different levels which play a vital role in cure of diseases. Toxic elements Cd and Pb were also found but at very low concentration. These results can give the importance about the wild edible fruits and used to set new standards for prescribing the dosage of the herbal drugs prepared from these plant materials in herbal remedies and in pharmaceutical companies.[...] Read More.

Keywords: Atomic absorption spectrometer (AAS), drugs, elements, Ficus, fruits, medicinal.

Full text

Download：983

文章

Stability- indicating (liquid chromatographic) LC method for the determination of rifabutin in bulk drug and in pharmaceutical dosage form

Full Length Research Paper

Abstract: A novel stability-indicating LC assay method was developed and validated for quantitative determination of Rifabutin in bulk drugs and in pharmaceutical dosage form in the presence of degradation products generated from forced degradation studies. An isocratic, reversed phase LC method was developed to separate the drug from the degradation products, using an Ace5-C18 (250 x 4.6 mm, 5 µm) column, and 50 mM ammonium acetate (pH- 4 by acetic acid) and acetonitrile (50:50v/v) as a mobile phase. The detection was carried out at the wavelength of 275 nm. The Rifabutin was subjected to stress conditions of hydrolysis (acid, base), oxidation, photolysis and thermal degradation. Degradation was observed for Rifabutin hydrolysis (acid, base), oxidation and photolysis conditions attempted. There is no degradation in thermal condition. The degradation products were well resolved from the main peak. The percentage recovery of Rifabutin ranged from (99.42 to 100.27%) in pharmaceutical dosage form. The developed method was validated with respect to linearity, accuracy (recovery), precision, specificity and robustness. The forced degradation studies prove the stability-indicating power of the method.[...] Read More.

Keywords: Rifabutin, column liquid chromatography, stability indicating method, validation.

Full text

Download：964

文章

Avoidable childhood death: A case of mismanagement and inappropriate medication use

Taha Nazir*, Syed Muzzamil Masood Zaidi, Ashfaq Ahmad and Tahir Aqeel

Abstract: Rational drug usage, clinical regulations and pharmaceutical care are important features of health practice. Thus; we have aimed case report to elaborate the clinical pharmaceutical services. A 3 year old girl, was presented in a hospital with minor burn that happened by spilt hot water on her wrist. She was in severe pain. The emergency ward staff applied an ointment. The doctor instructed injection Dormicum two times with short gape and then 3rd injection of Pavulon (Pancuronium). Patient went silent and started losing consciousness and eventually passed away. In view of the above facts and circumstances the inquiry board and judiciary took action against the negligence, mishandling. While; going through the investigation the inquiry board did not bothered the channel through which this injection came without proper check that is therapeutical drug monitoring, prescription reviewing, bio-safety and pharmaceutical evaluation. Furthermore, it is not a single death but representation of so many casualties because of the wrong medications. The medial practice needs some more legal, professional and principled restrictions to make sure the safe and correct therapy plans. The clinical legislation, drug rules and medical practice seriously need the attention of judiciary, society and leadership to assure the safety of precious live.[...] Read More.

Keywords: Wrong medication, medical malpractice, professional negligence, pharmaceutical services, Suo-moto notice of chief justice of high court.

Full text

Download：998

文章

Screening for anti-typhoid activity of some medicinal plants used in traditional medicine in Ebonyi state, Nigeria

Iroha I. R.*, ILang D. C., Ayogu T. E., Oji A. E. and Ugbo E. C.

Abstract: Ethanol, hot and cold crude water extracts of five medicinal plants namely Vitex doniana (root) , Cassia tora (Leaf), Alstonia boonei (bark), Stachytarpheta jamaicensis (leaf), and Carica papaya (leaf) used as traditionally medicine for anti Salmonella typhi activity in Ebonyi state were evaluated. These plants were screened in-vitro for anti-typhoid activity against 10 clinically selected isolates of S. typhi using the hole-plate diffusion method. The Minimum inhibitory concentration (MIC) of Ethanol, hot and cold water extract of each herbal plant was determined by broth dilution method. Ethanol extracts of Vitex doniana exhibited anti-typhoid activity against 9(90%) of the test organisms, A. boonei exhibited activity against 8(80%) of the test organisms, C. papaya against 2(20%), C. tora against 6(60%), and S. jamaicensis against 6(60%). Hot water extract of Vitex doniana showed anti-typhoid activity against 7(70%) of the test organisms, A. boonei against 9(90%), C. papaya against 1(10%), C. tora against 8(80%) and S. jamaicensis against 7(70%). Cold water extract of V. doniana, had anti-typhoid activity against 6(60%) of the test organisms, A. boonei, against 6(60%), C. papaya against 0(0%), C. tora against 6(60%) and S. jamaicensis against 4(40%). MIC of ethanol, hot and cold water extracts of V. doniana, A. boonei, C. papaya, C. tora and S. jamaicensis, fall within 0.4 -128, 0.8 -128, 64 -128, 32 – 128 and 32 – 128. MIC of hot water extracts were within 16 -128, 0.8 – 128, 128 -512, 0.8 – 512 and 0.8 – 128 while MIC of cold water extract are within 64 – 128, 64 – 512, 64 – 512, 64 – 512 and 128-512 respectively. Our findings showed that ethanol and hot water extracts of V. doniana and A. boonei had the best anti-typhoid activity followed by C. tora and S. jamaicensis while C. papaya showed no activity.[...] Read More.

Keywords: Salmonella typhi, medicinal plants extracts, anti-typhoid activity, minimum inhibitory concentration.

Full text

Download：985

文章

Activity induced by dihydrotestosterone-dihydropyrimidine derivative on perfusion pressure and coronary resistance in isolated rat heart

Figueroa-Valverde Lauro*, Díaz-Cedillo Francisco, Lopez-Ramos Ma, Garcia-Cervera Elodia and Quijano A. Karen

Abstract: Experimental and clinical studies suggest that dihydrotestosterone can be associated with changes in blood pressure. In this work, the effects induced by dihydrotestosterone and dihydrotestosterone-dihydropyrimidine on perfusion pressure and coronary resistance were evaluated, in isolated rat heart using the Langendorff flow model. Additionally, the molecular mechanism involved in the activity exerted by dihydrotestosterone-derivative was characterized. The results showed that dihydrotestosterone- dihydropyrimidine [10-9 mM] significantly increase the perfusion pressure (p = 0.005) and coronary resistance (p = 0.006) in isolated rat heart. Additionally, the activity exerted by dihydrotestosterone-dihydropyrimidine on perfusion pressure [109 to 10-4 mM] was blocked in the presence of nefidepine [10-6 mM].These data suggest that activity induced by dihydrotestosterone-derivative on perfusion pressure and coronary resistance is dependent upon its chemical structure. This phenomenon possibly involves the L-type calcium channel activation through a non-genomic molecular mechanism.[...] Read More.

Keywords: Dihydrotestosterone, perfusion pressure, vascular resistance.

Full text

Download：927

文章

Anticarcinogenic effect of turmeric on processed food products containing acrylamide

Akshaya Pandey, Prateek Garg and R. Balaji Raja*

Abstract: In present scenario Acrylamide concentration in processed food products have become a very serious health issue. The World Health Organization (WHO) and The Scientific Committee for Food (SCF) of the European Union also confirmed this concern. In laboratory scale, it was found that Acrylamide causes tumors in animals. It is even present in processed food free of microbes indicating the absence of microbial role in Acrylamide formation. This study was aimed to demonstrate the anti-carcinogenic effect of Acrylamide in the processed food products available in open market. In order to determine the acrylamide concentration in three processed food brands GC-MS technique was employed. Turmeric was found to bring about the anti-carcinogenic effect and lower down the acrylamide concentration in Aloo Paratha. No profound concentration of acrylamide was found in other two processed food products taken in for study. The processed food is found to be a Health hazard to the consumer and discretion of usage could minimize its impact.[...] Read More.

Keywords: Processed food, GC-MS, acrylamide, anti-carcinogen, turmeric.

Full text

Download：1023

文章

Impact of saffron as an anti-cancer and anti-tumor herb

Siavash Hosseinpour Chermahini*, Fadzilah Adibah Abd. Majid, Mohamad Roji Sarmidi, Ehsan Taghizadeh and Saleh Salehnezhad

Abstract: Cancer continues to represent the largest cause of mortality in the world and claims over 6 million lives each year. An extremely promising strategy for cancer prevention today is chemoprevention, which is defined as the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings. Plants, vegetables, herbs and spices used in folk and traditional medicine have been accepted currently as one of the main sources of cancer chemopreventive drug discovery and development. This review gives an overview from one of this herbs and spices that is saffron. The chemical composition of saffron has attracted the interest of several research groups during the last decades, and among the estimated more than 150 volatile and several nonvolatile compounds of saffron, approximately 40 – 50 constituents have already been identified. Oral administration of saffron extract inhibited the growth of mouse tumors that were derived from three different kinds of cancer cells and significantly increased the life spans of treated tumor-bearing mice.[...] Read More.

Keywords: Chemoprevention, volatile, tumor-bearing.

Full text

Download：965

文章

Changes in serum lipid profile following moderate exercise

Fahri Akçakoyun

Abstract: In this study, 90 middle- aged men were randomly assigned to exercise (E, n= 44) and control groups (C, n= 46) to examine the role of physical exercise on serum lipoproteins. While the exercise group participated in a 2-month training program, the control group maintained their previous exercise habits. Serum triglycerides decreased from 1.54 ± 0.10 to 1.27 ± 0.08 mmol/1 (p[...] Read More.

Keywords: Serum lipoproteins, physical exercise, middle aged men.

Full text

Download：959

文章

Evaluation of anti-hyperglycemic and free radical scavenging activity of Melothria maderaspatana Linn. in streptozotocin-induced diabetic rats

S. Hemalatha*, A. K. Wahi, P. N. Singh and J.P.N. Chansouria

Abstract: The anti-hyperglycemic activity of aqueous extract of Melothria maderaspatana Linn. was evaluted in streptozotocin-induced diabetic rats. Free radical scavenging activity of aqueous extract of M. maderaspatana was assessed in vitro using 1, 1-diphenyl-2-picryhydrazyl (DPPH). Oral administration of aqueous extract of M. maderaspatana significantly decreased the blood glucose level in normal and streptozotocin-induced diabetic rats. This extract also lowered the serum cholesterol, lipid peroxidation (LPO) and hepatic tissue LPO levels in streptozotocin-induced diabetic rats. M. maderaspatana showed free radical scavenging activity when assayed in an in vitro system using 1, 1-diphenyl-2-picryhydrazyl (DPPH) stable free radical. Pretreatment of M. maderaspatana failed to show any protective action against streptozotocin-induced diabetes. Aqueous extract of M. maderaspatana (2 g/kg p.o.) showed significant antihyperglycemic, hypocholesterolemic and free radical scavenging activities in streptozotocin-induced diabetic rats.[...] Read More.

Keywords: Antihyperglycermic activity, DPPH, free radical scavenging activity, LPO, Melothria maderaspatana, streptozotocin.

Full text

Download：964

Search Filter