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文章
Chang Ling Zhao*, Hua Chun Guo, Zhi Yuan Dong and Qing Zhao
Abstract: Colored potatoes are due to the accumulation of anthocyanins in the stem tubers. The strong antioxidative activity of potato anthocyanins results from the promotion effects of the anthocyanins on the activities of the antioxidant enzymes and is positively correlated to the anthocyanin content, which derives several important pharmacological actions. Both the antioxidative strength and anti-influenza virus activity of potato anthocyanins are determined by the molecular structures of the anthocyanins and this involves the synergic effects of the anthocyanins and other antioxidants in the tubers. In addition, potato anthocyanins may improve colonic environments. However, so far, the pharmacological and nutritional activities of potato anthocyanins are all verified initially by using model experimental systems and the total anthocyanins of the potatoes with specific colorations, the molecular mechanisms and the universality of the biomedicinal activities of potato anthocyanins are not yet well understood.[...] Read More.
Keywords: Colored potato, anthocyanin, pharmacological, nutritional activities.
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Full Length Research Paper
Abstract: Leaf and stem volatile oils were obtained differently from Hypoestes phyllostachya ‘Rosea’ (Acanthaceae) in 0.36 and 0.13% yields, respectively. GC -MS analyses revealed 38 compounds are responsible for 99.86% of the leaf oil, and 26 compounds make-up 99.89% of the stem oil. Identified compounds were 26 in leaf, which make-up 93.43% of it; 21 identified in stem, which represent 90.45% of it. Leaf oil is dominated by sesquiterpenoids (69.37%), while stem oil contain mostly sesquiterpene hydrocarbons (87.25%). Most abundant compounds in leaf oil are: -elemenone (20.04%), 8-cendren-13-ol (19.35%), 5-cendranone (10.60%), guaiol (4.43%), geranyl tinglate (4.30%) and germacrene B (4.21%). Prominent compounds in stem oil are: viridiflorene (31.28%), allo-aromadendrene (14.65%), acoradiene (6.99%), -gurjunene (4.15%) and valencene (3.97%) . The known ubiquitous monoterpenes are not in both leaf and stem essential oils. We report 20 other compounds in leaf oil, and 16 other compounds in stem oil as composition of Hypoestes phyllostachya ‘Rosea’ which is scarce in literature.[...] Read More.
Keywords: Hypoestes phyllostachya ‘Rosea’, acanthaceae, essential oils, gas chromatography-mass spectroscopy [GC-MS], sesquiterpenoids.
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文章
V. Ravi*, T. S. M. Saleem, P. P. Maiti, K. Gauthaman and J. Ramamurthy
Abstract: The present investigation designed to evaluate the phytochemical and pharmacological activity of ethanolic extract of Solanum nigrum in experimental animal models. The ethanolic extract of S. nigrum was used in three different doses (100, 200 and 300 mg/kg bw) to evaluating anti- inflammatory and anti-convulsant activity by employing carrageenan paw edema and Supramaximal electric shock (MES) methods. Ethanolic extract of S. nigrum produced significant anti-inflammatory (P < 0.01) and anti-convulsant (P < 0.05) effect in dose dependent manner. The flavonoids present in the berries might be a responsible active constituent for this activity.[...] Read More.
Keywords: Solanum nigrum, anti-inflammatory activity, anti-convulsant, flavonoids.
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文章
Mohaddes Gisou, Rasi Soheila and Naghdi Nasser*
Abstract: Leptin is a peptide hormone secreted by adipose tissue. Some studies have suggested that leptin may affect learning and memory. The hippocampus has been implicated in many learning and memory functions including spatial memory. The present study is scheduled to investigate the effect of intrahippocampal (IH) injection of different doses of leptin on spatial memory formation. 40 male rats were divided into 4 groups in our experiment: (1) sham (saline treated animals), and (2), (3), (4) intrahippocampal injection of 0.1, 0.5 and 1 µg doses of leptin respectively. All groups were trained in Morris water maze for two consecutive days. Learning parameters were compared among groups. Our results showed, there were significant differences of learning parameters between sham group and test groups in spatial learning. Lower dose of leptin improved spatial learning better than high dose. In conclusion, our findings indicate that leptin in the hippocampus is involved in memory processing in rat and suggests also that low levels of leptin may perform better.[...] Read More.
Keywords: Hippocampus, spatial memory, leptin, rat.
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文章
Agouzal M*, Benkirane R, Soulaymani A, Benjelloun R, Soulaymani-Bencheikh R, Quyou A
Abstract: Incidence of adverse drug reactions [ADRs] leads to many conflicting discussions about patients safety in many countries. It has been shown that ADRs are more frequent in outpatient department rather than indoors. We wanted to find out if there is similar situation in Morocco as well. Due to lack of National data we investigated the incidence of ADRs in patients of teaching hospital Ibn Sina in Rabat. Out of the total number of patients who attended the above hospital during study period of 5 days in February. Sample size 644. 113[17.54%] patients developed at least one ADR [nearly 1.47ADR/per patient]. Out of these patients 4 patients were hospitalized as a direct result of ADR. ADRs were more common in female patients then males. Maximum ADRs occurred in the age bracket of 40- 49 years. Maximum cases were recorded from Pnumology service. Large size and longer study period is required to get answer to our question.[...] Read More.
Keywords: Adverse drug reaction, serious adverse drug reactions, rate prevalence, transversal study, outpatients.
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Adeyemi Oluyomi S.*, Ekanem Justine T. and Sulyman Faoziyat
Abstract: Two antimalarial drugs; Halofantrine HCl and Artemether whose mechanism of action has been shown to depend on the disruption of the red blood cells during malarial infections were investigated for possible trypanocidal activity in vivo. Pre-treatment with Artemether before infection with the parasite had no effect on infected rat when compared to the control. Treatment at the early stage of infection extended the lifespan from 11 days for control to 13th and 14th days post infection for dose treatments at 4.6 and 2.3 mg/kg rat weight respectively. Similar results were obtained for late stage treatment. Pre-treatment with Halofantrine HCl extended the life span to 16 days at 7.1 mg/kg rat weight. Early stage treatment with 7.1 and 14.2 mg/kg rat weight extended life span to 14 and 13 days respectively even though parasitaemia kept decreasing until death of the animals. The late stage treatment however extended the life span to 18 days. A combination of both drugs maintained low parasitaemia and extended life span to 16 days for prophylactic treatment, 15 and 16 days for early stage treatment at 2.3 mg Artemether and 7.1 mg/Kg Halofantrine HCl; 4.6 and 14.2 mg/Kg rat weight respectively, and 19 days for late stage treatment. Results suggest that Halofantrine HCl and possibly Artemether could be useful in the management of trypanosomosis since both drugs were able to maintain low parasitaemia. Parasitaemia has been shown to correlates with the severity of infection.[...] Read More.
Keywords: Halofantrine, artemether, parasitaemia, trypanosomosis, red blood cells.
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文章
Niaz Ali*, Bashir Ahmad, Shumaila Bashir, Jehandar Shah, Sadiq Azam and Manzoor Ahmad
Abstract: The effects of crude methanolic extract of Withania coagulans (Wc.cr) were studied for possible calcium channel blocking activities in rabbit’s jejunum preparations at different doses. Potassium chloride (KCl) induced contractions were also inhibited by the Wc.cr extract suggesting calcium channel blocking activity. Calcium channel blocking activity was confirmed by the right shift in the dose response curves of the tissues in calcium free tyrode’s solution. The dose response curves of the Wc.cr resemble the curves produced by verapamil, a standard calcium channel blocker. The results confirm the presence of calcium channel blocker(s) in the extract and the plant species could be a potential target for activity-guided isolation of the active moieties.[...] Read More.
Keywords: Withania coagulans, spasmolytic, verapamil, calcium channel-blocking activity.
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Benjamin U. Ebeshi*, Kehinde E. Oseni, Augustine A. Ahmadu and James O. Oluwadiya
Abstract: The accuracy and reliability of the analytical results are critical in ensuring quality, safety, and efficacy of pharmaceutical products. However, to ensure these criteria, the choice of appropriate analytical method is required. This study sets out to compare the efficacy of visual, potentiometric titrations and UV spectrophotometric methods in the determination of the quality of Ibuprofen tablets in Nigeria. Eight different brands of Ibuprofen tablets were purchased from local pharmacies and drug stores. Visual, potentiometric titrations and UV spectrophotometric methods were utilized in the quantification of the different brands. The label claims of the various brands were assessed base on the different methods. The results obtained were compared with the official specification for uniformity. All the eight different brands of Ibuprofen tablets conform to the USP specification for the percent purity of the active principle using the visual titration, whilst one out of the eight brands did not conform to the USP specification with potentiometric titration as well as four out of the eight brands also, did not meet the official compendium specification using the UV spectrophotometric method. It can be inferred from this study that the choice of analytical method is critical in ascertaining the exact quality of pharmaceutical products.[...] Read More.
Keywords: Visual titration, potentiometric titration, UV spectrophotometry, analytical methods, Ibuprofen.
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I.  O. Okonko*, B. A. Onoja, A. O. Adedeji, A. A. Ogun, A. O. Udeze, J. Ejembi, K. N. Garba, O. C. Egun and A. Fowotade
Abstract: This review summarizes the role of vaccines in elimination and global eradication of measles-a review of literature. Measles eradication is defined as the interruption of measles transmission worldwide as a result of deliberate efforts; intervention methods may no longer be needed. It represents the sum of successful elimination efforts in all countries. Indeed, measles transmission has been interrupted in several countries, reinforcing the view that measles eradication is technically feasible using existing vaccines, laboratory techniques and intervention strategies. However, measles still accounts for 10% of global mortality from all causes among children aged less than 5 years (That is, approximately 1 million deaths annually). Vaccination proper coverage is key indicator of campaign success and to predict control on measles. In Nigeria where there is perennial, low routine vaccination coverage and where the quality of the mass immunization campaign is not high enough, large and persistent measles outbreaks continue to occur with high morbidity and mortality. Immunization and vaccination remains one of the most cost effective strategies to prevent infectious diseases. However, the most effective and efficient way to protect the health of children is by immunization before the risk of disease arises. Vaccination has succeeded in eradicating small pox in the world, soon would be achieved with polio and measles will be next to reach the same degree of disease control (viz, worldwide eradication) as has occurred with smallpox. The efficacy of vaccination and immunization in reducing the incidences of several diseases is clearly shown by the success story of measles control in developed countries of the world. However, intensified efforts are necessary to implement appropriate control and elimination strategies, including supplementary vaccination campaigns, expansion of routine vaccination services, and surveillance.[...] Read More.
Keywords: Antibody, elimination, eradication, immunization, measles, measles virus, measles vaccine, vaccination.
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文章
O. O. Oguntibeju*, A. J. Esterhuyse and E. J. Truter
Abstract: Recently, several reports have indicated that individuals living with HIV/AIDS undergo a condition of chronic oxidative stress with a resultant decline in nutritional antioxidants and other micronutrients. It has also been reported that these micronutrient deficiencies interfere with immune functions, weaken epithelial integrity, contribute to oxidative stress and enhance HIV disease progression. Reports from observational studies have led to an increasing interest in the possible benefits of micronutrient supplementation as a cost-effective strategy for improving oxidative and nutritional status. Micronutrient supplementation may also assist in the possible prevention of vertical transmission of HIV from mother to child especially in low -income countries where antiretroviral therapy and prophylactic drugs are not readily available. However, there are conflicting reports from other observational studies as to the usefulness or benefits of micronutrient supplementation in the treatment and management of HIV/AIDS. In this review we examine possible benefits of micronutrient supplementation in the treatment and management of HIV infection and AIDS.[...] Read More.
Keywords: Vitamins, antioxidants, micronutrients, supplementation, HIV infection, AIDS.
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