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文章
Mohaddes Gisou, Rasi Soheila and Naghdi Nasser*
Abstract: Leptin is a peptide hormone secreted by adipose tissue. Some studies have suggested that leptin may affect learning and memory. The hippocampus has been implicated in many learning and memory functions including spatial memory. The present study is scheduled to investigate the effect of intrahippocampal (IH) injection of different doses of leptin on spatial memory formation. 40 male rats were divided into 4 groups in our experiment: (1) sham (saline treated animals), and (2), (3), (4) intrahippocampal injection of 0.1, 0.5 and 1 µg doses of leptin respectively. All groups were trained in Morris water maze for two consecutive days. Learning parameters were compared among groups. Our results showed, there were significant differences of learning parameters between sham group and test groups in spatial learning. Lower dose of leptin improved spatial learning better than high dose. In conclusion, our findings indicate that leptin in the hippocampus is involved in memory processing in rat and suggests also that low levels of leptin may perform better.[...] Read More.
Keywords: Hippocampus, spatial memory, leptin, rat.
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文章
Agouzal M*, Benkirane R, Soulaymani A, Benjelloun R, Soulaymani-Bencheikh R, Quyou A
Abstract: Incidence of adverse drug reactions [ADRs] leads to many conflicting discussions about patients safety in many countries. It has been shown that ADRs are more frequent in outpatient department rather than indoors. We wanted to find out if there is similar situation in Morocco as well. Due to lack of National data we investigated the incidence of ADRs in patients of teaching hospital Ibn Sina in Rabat. Out of the total number of patients who attended the above hospital during study period of 5 days in February. Sample size 644. 113[17.54%] patients developed at least one ADR [nearly 1.47ADR/per patient]. Out of these patients 4 patients were hospitalized as a direct result of ADR. ADRs were more common in female patients then males. Maximum ADRs occurred in the age bracket of 40- 49 years. Maximum cases were recorded from Pnumology service. Large size and longer study period is required to get answer to our question.[...] Read More.
Keywords: Adverse drug reaction, serious adverse drug reactions, rate prevalence, transversal study, outpatients.
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Adeyemi Oluyomi S.*, Ekanem Justine T. and Sulyman Faoziyat
Abstract: Two antimalarial drugs; Halofantrine HCl and Artemether whose mechanism of action has been shown to depend on the disruption of the red blood cells during malarial infections were investigated for possible trypanocidal activity in vivo. Pre-treatment with Artemether before infection with the parasite had no effect on infected rat when compared to the control. Treatment at the early stage of infection extended the lifespan from 11 days for control to 13th and 14th days post infection for dose treatments at 4.6 and 2.3 mg/kg rat weight respectively. Similar results were obtained for late stage treatment. Pre-treatment with Halofantrine HCl extended the life span to 16 days at 7.1 mg/kg rat weight. Early stage treatment with 7.1 and 14.2 mg/kg rat weight extended life span to 14 and 13 days respectively even though parasitaemia kept decreasing until death of the animals. The late stage treatment however extended the life span to 18 days. A combination of both drugs maintained low parasitaemia and extended life span to 16 days for prophylactic treatment, 15 and 16 days for early stage treatment at 2.3 mg Artemether and 7.1 mg/Kg Halofantrine HCl; 4.6 and 14.2 mg/Kg rat weight respectively, and 19 days for late stage treatment. Results suggest that Halofantrine HCl and possibly Artemether could be useful in the management of trypanosomosis since both drugs were able to maintain low parasitaemia. Parasitaemia has been shown to correlates with the severity of infection.[...] Read More.
Keywords: Halofantrine, artemether, parasitaemia, trypanosomosis, red blood cells.
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Niaz Ali*, Bashir Ahmad, Shumaila Bashir, Jehandar Shah, Sadiq Azam and Manzoor Ahmad
Abstract: The effects of crude methanolic extract of Withania coagulans (Wc.cr) were studied for possible calcium channel blocking activities in rabbit’s jejunum preparations at different doses. Potassium chloride (KCl) induced contractions were also inhibited by the Wc.cr extract suggesting calcium channel blocking activity. Calcium channel blocking activity was confirmed by the right shift in the dose response curves of the tissues in calcium free tyrode’s solution. The dose response curves of the Wc.cr resemble the curves produced by verapamil, a standard calcium channel blocker. The results confirm the presence of calcium channel blocker(s) in the extract and the plant species could be a potential target for activity-guided isolation of the active moieties.[...] Read More.
Keywords: Withania coagulans, spasmolytic, verapamil, calcium channel-blocking activity.
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Benjamin U. Ebeshi*, Kehinde E. Oseni, Augustine A. Ahmadu and James O. Oluwadiya
Abstract: The accuracy and reliability of the analytical results are critical in ensuring quality, safety, and efficacy of pharmaceutical products. However, to ensure these criteria, the choice of appropriate analytical method is required. This study sets out to compare the efficacy of visual, potentiometric titrations and UV spectrophotometric methods in the determination of the quality of Ibuprofen tablets in Nigeria. Eight different brands of Ibuprofen tablets were purchased from local pharmacies and drug stores. Visual, potentiometric titrations and UV spectrophotometric methods were utilized in the quantification of the different brands. The label claims of the various brands were assessed base on the different methods. The results obtained were compared with the official specification for uniformity. All the eight different brands of Ibuprofen tablets conform to the USP specification for the percent purity of the active principle using the visual titration, whilst one out of the eight brands did not conform to the USP specification with potentiometric titration as well as four out of the eight brands also, did not meet the official compendium specification using the UV spectrophotometric method. It can be inferred from this study that the choice of analytical method is critical in ascertaining the exact quality of pharmaceutical products.[...] Read More.
Keywords: Visual titration, potentiometric titration, UV spectrophotometry, analytical methods, Ibuprofen.
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I.  O. Okonko*, B. A. Onoja, A. O. Adedeji, A. A. Ogun, A. O. Udeze, J. Ejembi, K. N. Garba, O. C. Egun and A. Fowotade
Abstract: This review summarizes the role of vaccines in elimination and global eradication of measles-a review of literature. Measles eradication is defined as the interruption of measles transmission worldwide as a result of deliberate efforts; intervention methods may no longer be needed. It represents the sum of successful elimination efforts in all countries. Indeed, measles transmission has been interrupted in several countries, reinforcing the view that measles eradication is technically feasible using existing vaccines, laboratory techniques and intervention strategies. However, measles still accounts for 10% of global mortality from all causes among children aged less than 5 years (That is, approximately 1 million deaths annually). Vaccination proper coverage is key indicator of campaign success and to predict control on measles. In Nigeria where there is perennial, low routine vaccination coverage and where the quality of the mass immunization campaign is not high enough, large and persistent measles outbreaks continue to occur with high morbidity and mortality. Immunization and vaccination remains one of the most cost effective strategies to prevent infectious diseases. However, the most effective and efficient way to protect the health of children is by immunization before the risk of disease arises. Vaccination has succeeded in eradicating small pox in the world, soon would be achieved with polio and measles will be next to reach the same degree of disease control (viz, worldwide eradication) as has occurred with smallpox. The efficacy of vaccination and immunization in reducing the incidences of several diseases is clearly shown by the success story of measles control in developed countries of the world. However, intensified efforts are necessary to implement appropriate control and elimination strategies, including supplementary vaccination campaigns, expansion of routine vaccination services, and surveillance.[...] Read More.
Keywords: Antibody, elimination, eradication, immunization, measles, measles virus, measles vaccine, vaccination.
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O. O. Oguntibeju*, A. J. Esterhuyse and E. J. Truter
Abstract: Recently, several reports have indicated that individuals living with HIV/AIDS undergo a condition of chronic oxidative stress with a resultant decline in nutritional antioxidants and other micronutrients. It has also been reported that these micronutrient deficiencies interfere with immune functions, weaken epithelial integrity, contribute to oxidative stress and enhance HIV disease progression. Reports from observational studies have led to an increasing interest in the possible benefits of micronutrient supplementation as a cost-effective strategy for improving oxidative and nutritional status. Micronutrient supplementation may also assist in the possible prevention of vertical transmission of HIV from mother to child especially in low -income countries where antiretroviral therapy and prophylactic drugs are not readily available. However, there are conflicting reports from other observational studies as to the usefulness or benefits of micronutrient supplementation in the treatment and management of HIV/AIDS. In this review we examine possible benefits of micronutrient supplementation in the treatment and management of HIV infection and AIDS.[...] Read More.
Keywords: Vitamins, antioxidants, micronutrients, supplementation, HIV infection, AIDS.
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文章
Berhanemeskel Weldegerima
Abstract: This paper reviews and discusses the importance of documenting ethnopharmacological information on medicinal plants. The literature review was done by collecting relevant information from journal articles, workshop proceedings, books and electronic resources. The review sums up the importance of documenting the indigenous traditional knowledge on medicinal plants as being a vehicle for; (i) preserving cultural heritage, (ii) ethnopharmacological bases of drug research and (ii) preserving of biological diversity.[...] Read More.
Keywords: Ethnopharmacology, indigenous knowledge, medicinal plants, biological and diversity.
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文章
Khoza-Shangase Katijah*, Mupawose Anniah and Mlangeni Ntsako Precious
Abstract: This project aimed to determine awareness of South African adults with tuberculosis (TB) of the ototoxic effects of TB medication. 60 adults undergoing TB treatment in Gauteng participated. A semi-structured interview schedule was utilized to collect data. Data analysis used descriptive statistics. Results revealed a generalized lack of awareness amongst the participants regarding TB as a disease, its symptoms and how it is contracted; with 50% of the participants lacking awareness of the importance of adherence to treatment. Furthermore, even though 63% of participants reported auditory symptoms since commencement of treatment, none of them had been referred to an audiologist or an Ear, Nose and Throat specialist for management. In fact none of the participants were enrolled in an ototoxicity monitoring programme, even though 48% of the participants with auditory symptoms reported these symptoms having an impact in their daily lives. Current findings highlight the need for comprehensive counselling and education of patients on ototoxic medications through development and implementation of ototoxicity monitoring programmes as part of patient management.[...] Read More.
Keywords: Aminoglycosides, ototoxicity, hearing loss, tuberculosis, streptomycin, adults, audiologist, otolaryngology.
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文章
Judith Parra-Vizuet, Abelardo Camacho-Luis, Eduardo Madrigal-Santillan, Mirandeli Bautista, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Manuel García Luna y González Rubio, Jorge Alberto Mendoza-Pérez, Jorge Chanona-Pérez and José A. Morales-González*
Abstract: Our objective was to demonstrate the protective effect of glycine (Gly) and vitamin E (VE) on a model of ethanol-induced acute liver injury during the early phase of liver regeneration after partial hepatectomy (PH) in rats. Fifty male Wistar rats (body weight (b.w.), 240 - 280 g) were divided into four groups (n = 10, each, respectively) as follows: 1) control partial hepatectomy (PH), 70%; 2) PH + ethanol (EtOH) at 1.5 g/kg b.w; 3) PH + Gly (0.6 g/kg b.w) + EtOH, and; 4) PH + VE (400 International units [IU]) + EtOH. Twenty four h after surgery, animals were killed and liver damage and oxidative stress parameters were measured. Ethanol caused a decrease in serum albumin (2.27 vs 3.12 g/dL; p < 0.05), cholesterol (31.4 vs 48.0 mg/dL; p < 0.05), Aspartate aminotransferase (AST, 70 vs 380 UI; p < 0.05), and alanine aminotransferase (ALT, 110 vs 170 UI; p < 0.05) in comparison with the PH control group, but these decreases were reverted with either Gly or VE administration. Furthermore, Gly and VE administration decreased (p < 0.05) Thiobarbituric acid reactive (TBARS) levels, stimulated superoxide dismutase (SOD) activity, and a significant restitution of liver weight was observed. Our results suggested a protective effect against liver injury with glycine and VE supplementation. Treatment with either Gly or VE causes an elevation in total SOD activity and a decrease in TBARS levels, showing a protective effect in liver regeneration on a model of ethanol-induced acute liver injury after PH in rats.[...] Read More.
Keywords: Antioxidants, ethanol-induced liver injury, free radicals, glycine, liver regeneration, vitamin E.
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