Spica Prunellae extract promotes mitochondrion-dependent apoptosis in human colon carcinoma cell line

Liangpu Zheng¹, Youqin Chen^2,4, Wei Lin¹, Qunchuan Zhuang¹, Xuzheng Chen¹, Wei Xu³, Xianxiang Liu¹, Jun Peng¹* and Thomas J. Sferra^2,4

¹Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, 1 Huatuo Road, Minhou Shangjie, Fuzhou, Fujian 350108, China.

²Department of Pediatrics, The University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, Oklahoma City, OK 73190, USA.

³Department of Pharmacology, Fujian University of Traditional Chinese Medicine, 1 Huatuo Road, Minhou Shangjie, Fuzhou, Fujian 350108, China.

⁴Department of Biochemistry and Molecular Biology, The University of Oklahoma Health Sciences Center, 940 Stanton L. Young Boulevard, Oklahoma City, OK 73190, USA.