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N. Mishra, S. D. Rout and T. Panda*
Abstract: This paper documents zootherapeutic practices in Similipal Biosphere Reserve of Mayurbhanj district, Orissa, India. It is primarily based on field surveys carried out in villages, where dwellers provided information on animal species used as medicine, body parts used to prepare the remedies, and the illnesses to which the remedies were prescribed. The dominant tribes involved in using animal parts as medicines in the district are Santhal, Kol, Bhumija, Bhuyan, Mahalis, Sounti and Saharas. The animal parts, namely, blood, excreta, feather and hair were used in raw or cooked forms for the treatment of piles, asthma, skin diseases, fever and rheumatism.The species used as medicinal drug and their respective families were: Bos gaurus gaurus(Mammalia), Buceros bicormis (Bucerotidae), Crocodylus palustris (Crocodilidae), Pavo cristatus(Phasianidae), Hystrix indica (Rodentia), Pterocarpus giganteus (Chiroptera) and Sus scorofacristatus (Mammalia).These zootherapeutical resources were used for the cure of 12 illnesses.[...] Read More.
Keywords: Ethnomedicine, ethnozoology, Orissa, Similipal, traditional knowledge, zootherapy
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Ramica Sharma*, Chetan Kumar, Shaveta Gangwani, Gurfateh Singh Sugga and A. C. Rana
Abstract: Resistin belongs to a family of cysteine- rich secreted polypeptides produced by monocy-tes/macrophages. It is also regarded as a novel adipokine that has been suggested to play a role in the development of insulin resistance and obesity. In humans, inflammatory cells seem to be the major source of resistin. Resistin has been suggested to be an independent risk factor involved in the pathogenesis of numerous disorders. Cardiovascular complications account for significant morbidity and mortality. Moreover, resistin has been demonstrated to play a pivotal role in the pathogenesis of various vascular disorders such as atherosclerosis, hypertension, coronary artery disease and heart failure. Hence, the present review discussed the role of resistin in the pathogenesis of cardiovascular disorders.[...] Read More.
Keywords: Resistin, cardiovascular disorders, adipokine, cysteine, macrophages, monocytes.
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*Murutala Adu, Wole Achebe and Shehu Abubakar
Abstract: The aim of this study seeks to investigate the presence of steroids, triterpenes, alkaloids, saponins, tannins, anthraquinones and flavonoids compounds as the possible agent responsible for the medicinal activities of the leaf of the plant Paullinia pinnata and also to carry out phytochemical screening of the dried leaf of the plant, to extract and fractionate the leaf and finally to carry out thin layer chromatography of the different fractions. In the phytochemical investigation of the plant, the powdered leaves was tested positive for steroids, triterpenes, alkaloids, saponins, tannins, anthraquinones and flavonoids. The presence of the constituents was also found to be similar to those reported for most medicinal plants. In East Africa, the leaves are used against snake bites, rabies, mental problems, blindness and eye troubles, together with the roots, against gonorrhoea, paralysis, wounds, threatened abortion, malaria, ancylostomiasis, and to expel placenta. Roots are applied against eczema, as a tonic and as a styptic medicine.[...] Read More.
Keywords: Paullinia pinnata, phytochemical, chromatography, flavanoids, alkaloids, materials, tests, tannins, extraction, colour, spray, fractionate.
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*Antonio Kabila, Augustine Tshombe and Kaumba E. B
Abstract: Results from the in vitro evaluation of the antibacterial and antifungal activities of six plant extracts indicated that the aqueous and the methanol extracts of Acalypha wilkesiana leaves and Ageratum conyzoides leaves exhibited good and efficient antifungal activity against Candida albicans with minimum inhibitory concentration (MIC) of 31.25 µg/ml and minimum fungicidal concentration (MFC) of 62.5 µg/ml) while the methanol extract from Pentaclethra macrophylla inhibited the yeast growth with minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 62.5 and 125 µg/ml respectively. The aqueous extracts from Acalypha wilkesiana, Ageratum conyzoides, Buccholzia tholoniana seeds, Gulboutia demeusei root and the aqueous and methanol extracts from Pentaclecthra macrophylla stem bark showed good antibacterial activity against Escherichia coli, Klebsiella oxytoca, Proteus mirabilis, Salmonella thyphimurium, Stahylococcus aureus and Shigella flexneri with minimum inhibitory concentration (MIC) of 62.5 µg/ml and minimum bactericidal concentration (MBC) of 125 µg/ml according to the case. These results partly support and justify the traditional use of these plant extracts for treating infections in traditional medicine.[...] Read More.
Keywords: Plant extracts, antibacterial, antifungal, infections.
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*Atiur Choudhury, Munier Huseyn and Muhammed Shaheed
Abstract: We have evaluated the phytochemical and bioactive nature of the leaves of Mallotus peltatus (Geist.) Muell. Arg. var acuminatus and Alstonia macrophylla Wall ex A. DC, the two major ethno medicines of the Onge, Nicobarese and other tribes of Andaman and Nicobar Islands, on the Bay of Bengal, India. Three major compounds were isolated from the polar fractions of the methanol extracts of A. macrophylla leaf namely -sitosterol (fraction A), ursolic acid (fraction B) and -sitosterol -D-glucoside (fraction C), along with a minor fraction containing alkaloid and fatty acids. On the other hand polar fractions of methanol extract of M. peltatus leaf yielded two major compounds, ursolic acid (fraction A) and -sitosterol (fraction B), along with a minor fraction containing fatty acids. The earlier studies reveal that both the extracts have antibacterial, antiinflammatory, antipyretic and analgesic activities, but the present study showed that the activities are due to fractions A and B of both the plants. Moreover, the extracts of both the plants had significant dose dependent antiinflammatory and antioxidant activity at nontoxic concentrations. It can be thus concluded that the terpenoid and - sitosterol, along with other minor constituent of the bioactive parts had a dose dependent therapeutic efficacy, justifying their use. However, further study can help to elucidate their mechanism of action.[...] Read More.
Keywords: Ethnomedicine, Alstonia macrophylla, Mallotus peltatus, pharmacology and phytochemistry, antibacterial, antioxidant, antiinflammatory activity.
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*Zafir Zahid, Moudud Fazlul and Mohammed Karim
Abstract: COCCINIA INDICA (Bimba, kanduri, Cucurbitaceae) is famous for its hypoglycemic and antidiabetic properties in Ayurvedic system of medicine. Other applications include the therapy of various conditions such as skin diseases and gonorrhoea. The present review highlights the phytochemistry and pharmacology of COCCINIA INDICA. There are many patented formulations derived from C. INDICA which are now distributed increasingly all over the world. This has given rise to a concomitant increase in research on the phytochemical constituents and biological activity of C. INDICA.[...] Read More.
Keywords: Coccinia indica, hypoglycemic, antidiabetic, saponins, terpenoids, sterol.
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*Zainul D. Karim, Shamsur E. A and Tahmima Ali
Abstract: The ethanol extract of the dried leaves of Mikania cordata (Family-Asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p[...] Read More.
Keywords: Antimicrobial, antinociceptive, asteraceae, cytotoxic, Mikania cordata.
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*Kishore Subhas, Mohan Kapoor and Akshay R. P
Abstract: The ethno medicinal plant Basella alba belongs to the family Basellaceae, and commonly known as malabar spinach, indian spinach, ceylon spinach and vine spinach. Although it has been reported in ancient systems of medicine, it did not gain much importance and has always remained controversial. It has been found to be a good source of calcium, iron, vitamin A and vitamin C. In the Indian system of medicine, the plant has immense potential in androgenic activity, antiulcer activity, antioxidant, cytotoxic and antibacterial activity, anti-inflammatory activity, central nervous system (CNS) depressant activity, nephroprotective and wound healing properties etc. The present is therefore, an effort to give a detailed survey of literature on pharmacognostical, phytochemical, ethnopharmacology as well as the pharmacological activities of the plant.[...] Read More.
Keywords: Nephroprotective, cytotoxic, androgenic, antiulcer activity, antioxidant, spinach.
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*Salman Ray, Aamir Roshan and Narenda Khan
Abstract: Quantification of bioactive principles through modern analytical tools is essential for establishing the authenticity and creditability of prescription and usage of herbal drugs. In the present study, simultaneous quantification of vasicine and vasicinone, present in SIDA species (Malvaceae), by reverse phase HPLC and HPTLC methods were developed. In the RP-HPLC method, the extracts were resolved using a mobile phase of acetonitrile - 0.1 M phosphate buffer - glacial acetic acid (15:85:1, V/V/V) with pH 4.0 on a C18-ODS-Hypersil column in isocratic mode. The retention times of vasicine and vasicinone were 5 and 8.7 min, respectively. In the HPTLC method, mobile phase of ethyl acetate, methanol, ammonia (8:2: 0.2, V/V) was used on precoated plate of silica gel 60 F254 and quantified by densitometric method. Validation of the methods was done to demonstrate its selectivity, linearity, precision and accuracy as recommended in the ICH guidelines. Excellent linear behaviors over the investigated concentration ranges were observed with the values of R2 higher than 0.998 for both the analytes. Recovery values between 97 - 101%, and correlation coefficient between (linear dynamic range) 0.977 - 0.9999 shows that the developed methods were accurate and precise. These methods can be employed for the routine analysis of the quality of herbal extracts and formulations.[...] Read More.
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*Ibrahim Bello, Yakubu Chris and Herbert Akintola
Abstract: Garcinia kola is widely consumed habitually and used as traditional remedy for various diseases in Nigeria. However, information with respect to the effect of using different solvents of extraction on its antioxidant properties is scanty. Therefore, the present study investigates the effect of different solvents on the phytochemical constituents and antioxidant properties of G. kola. Phytochemicals measured were the total phenolics, flavonoids and vitamin C content while the antioxidant parameters assessed were the free radical scavenging, Fe (II) - chelating and Fe3+ reducing properties. Finally, the ability of both extracts to offer protective benefits to both hepatic and cerebral tissues placed under oxidative assault induced by FeSO4 and sodium nitroprusside (SNP) was also investigated. The phenolic content of G. kola was estimated to be 45.2 ± 0.9 mg/g and 30.3 ± 0.4 mg/g gallic acid equivalent (GAE) for the ethanolic and aqueous extracts, respectively. Whereas the flavonoid content was estimated to be 29.2 ± 0.2 mg/g and 10.8 ± 0.2 mg/g quercetin equivalent (QE) for the ethanolic and aqueous extracts, respectively. In addition, the vitamin C contents were 21.2 ± 0.4 mg/g and 20.8 ± 0.1 mg/g for the ethanolic and aqueous extract of dried G. kola, respectively. In all the antioxidant indices measured, the ethanolic extract possessed significantly higher properties than the aqueous extract (p < 0.05). In view of all, the use of G. kola for the treatment of cough and liver disorders in folkloric medicines may be related to its phytochemical content. Hence, moderate consumption of the fruit should be encouraged as antioxidant supplement.[...] Read More.
Keywords: Garcinia kola, antioxidant, ethanolic, aqueous and phytochemical.
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