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*Shankar Salman, Khan V. Bachchan and Swami V. singh
Abstract: In existing study, we carried out an efficient record of the comparative antioxidant activity in methanolic extract of the selected parts (leaves, root and stem bark) of Aegle marmelos. Total content of phenol and flavonoid was quantitatively estimated in different parts of A. marmelos. The total phenolic contents varied from 9.8367 ± 0.0235 to 1.7281 ± 0.049 mg g-1. Total flavonoid contents were between 8.248 ± 0.029 to 1.087 ± 0.002 mg g-1. Free radical scavenging activity of different extracts was evaluated by using DPPH (1, 1 -Diphenyl- 2 -picryl hydrazyl) method. The highest free radical scavenging effect was observed in leaves with IC50 = 2.096µg ml –1. The effectiveness of radical scavenging activity of leaves extract was about 10 times greater than reference antioxidant butylated hydroxy toluene (BHT). The greater amount of phenolic compounds leads to more powerful radical scavenging effect as shown by methanolic extract of A. marmelos leaves.[...] Read More.
Keywords: Aegle marmelos, antioxidant, flavonoids, phenols, 1, 1 –diphenyl - 2 -picryl hydrazyl.
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文章
*Shankar Salman, Khan V. Bachchan and Swami V. singh
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*Mujibur Abed, Rahman E. Shakib and Khan Ahmed
Abstract: The ethanol extract of the dried leaves of Mikania cordata (Family-Asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p[...] Read More.
Keywords: Antimicrobial, antinociceptive, asteraceae, cytotoxic, Mikania cordata.
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*Moshood Musa, Ibrahim Mohammed and Murutala Achebe
Abstract: This study investigated the phytoconstituents in Neem (seed and flower), Jatropha curcas (stem and root bark) and grape (stem bark and leaves) in some selected solvents. Phytochemical screening revealed the presence of bioactive compound saponin in all the parts of the three plants in water extract only. Saponin was absent in other solvents used (ethanol, ethyl acetate, propan-2-ol, methanol, n-butanol and acetone). Ethanol, ethyl acetate and methanol were the most promising solvents to extract flavonoids in both the seed and flower of Neem plant. Acetone and ethanol were the most promising solvents to extract flavonoids in the stem bark of J. curcas. In the root bark of J. curcas, acetone and ethyl acetate were the most promising solvents to extract flavonoids. In grape (Citrus paradisi) leaves, ethanol, water and acetone were the most promising solvents to extract flavonoids. In the stem bark of grape, water, ethyl acetate and acetone proved promising as extraction solvents for flavonoids. All the parts of the plants studied were positive for alkaloid in ethanol and acetone extracts. The seed extract of Neem (Azadirachta indica) was strongly positive in ethanol only. Terpenoids were detected in ethyl acetate and n-butanol in all the parts of the three plants. Aged flower extract of Neem plant with pale pink colour could be exploited as a novel source of colourant. Volatile oil was not restricted to J. curcas stem and root barks, it was also present in C. paradisi stem and root barks. The nutritional significance, economic and toxicological implications of phytoconstituents analysed in the plants were discussed.[...] Read More.
Keywords: Phytomedicine, bioactive compounds, natural product, drug discovery, preventive medicine.
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文章
Dr. Tahir Mehmood Khan ,

 International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 8 (2), pp. 001-003, February, 2019. © International Scholars Journals

Editorial

 

Quality use of antidepressants: how Pharmacists can play their part

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文章
Babalola C. P.*, Awoleye S. A., Akinyemi J. O. and Kotila O. A.
Abstract: Drug therapy is the most commonly used method of any disease treatment in general practice. However, the patterns of drug prescription are often inappropriate and the need for registration of these patterns is essential in an effort to improve prescription standards. Retrospective analysis of prescriptions written by various cadres in primary health care department with emphasis on primary health care centers, dispensaries and health posts in four randomly selected local government areas were collected over a period of one year (March 2006 to February 2007). Data was collected using a standardized WHO instrument for studies of rational drug use. The average number of drugs per encounter was 6.11 with 69.81% drugs prescribed by generic names. The use of antibiotics (50.10% of encounters) and injections (72.70% of encounters) was relatively high. About ninety four percent(94%) of drugs prescribed were from the essential drugs list. It is obvious that poly pharmacy is high at the grassroots level coupled with shortage of high skilled manpower. The use of antibiotics and injections is also very high. Recruitment of skilled personnel and continuing educational programs for primary health care workers is recommended.[...] Read More.
Keywords: Prescription pattern, injections, antibiotics, primary health care.
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Syed Wasif Gillani*, Syed Azhar Syed Sulaiman, Yaseen Khalid, Yelly Oktavia Sari, Mirza Baig and Atif Amin
Abstract: Sex is a natural and basic drive of human beings. In Malaysia, erectile dysfunction (ED) is a common problem, affecting 16 to 47% of men above 40 years old. Erectile dysfunction (ED) is a common complication of diabetics, with prevalence ranging between 27 and 75%. Knowledge and perception are essential precursors of ED related quality of life. A cross-sectional study was conducted in Pulau Pinang, Malaysia, to produce the preliminary information to compare the knowledge and the perception of diabetic and non diabetic population towards sexual activity and the effect of ED on quality of life. Population based survey includes the entire male respondent in the community with age of 18 years and above. Investigator personally approached the respondents and asked them to complete self administered and anonymous pre-validated questionnaire. Statistical package for social sciences (version 15®) was used to analyze the data by adopting chi-square, univariate and multivariate analysis, ANOVA, T-test techniques, respectively. Data was collected from 1700 males aged between 20 years and above with response rate of 88.35%. The mean total knowledge score obtained by diabetics was significantly (p[...] Read More.
Keywords: Diabetics mellitus, perception and quality of life, erectile dysfunction, erectile and diabetics, diabetics and quality of life, erectile dysfunction treatment.
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Obinna Ikechukwu Ekwunife and Cletus Nze Aguwa
Abstract: This study aimed at synthesizing population-based studies on prevalence of hypertension in Nigeria from 1990 to 2009. General databases and subject-specific databases were searched for primary studies. Manuscripts of appropriate studies were retrieved. Based on some criteria, only eligible studies were included in the study. A total of 9 studies all from South-West region of Nigeria that fulfilled the inclusion criteria were retrieved. Prevalence of hypertension ranged from a minimum of 12.4% to a maximum of 34.8%. Combined prevalence rate of hypertension was 22% and with 95% confidence interval of 17 to 27%. There was also gender difference with respect to prevalence of hypertension as males had higher prevalence of hypertension compared to females. This study showed that prevalence of hypertension is high in Nigeria. There is a need to develop strategies to prevent, treat, and control hypertension effectively in Nigeria.[...] Read More.
Keywords: Hypertension, prevalence, epidemiology, meta analysis.
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Khalid S. Al-Numair, Govindasamy Chandramohan* and Mohammed A. Alsaif
Abstract: Non-enzymatic glycation of proteins, leading to chemical modification and cross-linking are of importance in the pathology of diabetic complications. In our early reported we showed that, camel milk possesses antihyperglycemic, antihyperlipidemic and exhibit beneficial role on membrane-bound ATPases in streptozotocin-diabetic rats after 45 days of treatment of camel milk at the optimum dose of 250 ml/day. In the present study, the effect of camel milk on the glycation and cross-linking of collagen from tail tendon of streptozotocin (STZ)-diabetic rats. Diabetes was induced in adult male albino rats of the Wistar strain, weighing 180 to 200 g, by administration of streptozotocin (STZ) (40 mg/kg) intraperitoneally. The animals were randomly divided into five groups of six animals each. Rats of groups II and IV were fed 250 ml of raw camel milk daily through watering bottle instead of water. Whereas animals in groups I, III and V were given tap water, and rats of group V were given 600 µg/kg body weight of glibenclamide orally, once in a day in the morning for 45 days. The levels of hydroxylproline and total collagen content elevated in the tail tendon of the diabetic control. The levels of extent of glycation and fluorescence of collagen increased while decreased levels of acid, neutral and pepsin soluble collagens were observed in the tail tendon of diabetic rats. These changes were alleviated by the simultaneous ingestion of camel milk. Our results demonstrate that intake of camel milk has a positive influence on tail tendon collagen glycation and other variables in STZ-diabetic rats and its effect was comparable with glibenclamide.[...] Read More.
Keywords: Camel milk, glycation, collagen, streptozotocin, diabetes.
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K. Prakash, Rama Rao Kalakuntla,* and Jayapal Reddy Sama
Abstract: The combination of Dipyridamole and Aspirin and is widely used to reduce thrombosis in patients with thrombotic diseases. A rapid, simple, precise and cost effective and reversed-phase high performance liquid chromatography (RP-HPLC) method has been developed and validated for the simultaneous determination of Aspirin and Dipyridamole in pharmaceutical formulations. Separation of both Aspirin and Dipyridamole was achieved within 5 min with required resolution, accuracy and precision thus enabling the utility of the method for routine analysis. Chromatographic separation was achieved on a waters symmetry C18 3.5 µm, 50 x 4.6 mm using a mobile phase consisting of 0.1% ortho phosphoric acid and acetonitrile in the ratio of 75:25 at a flow rate of 1.0 ml per minute. The detection was made at 227 nm and the retention time of Aspirin and Dipyridamole were1.5 and 2.8 minutes respectively. The method was found linear over the range of 4 to 80 µg/ml for Dipyridamole and 0.5 to 10 µg/ml for Aspirin.[...] Read More.
Keywords: Aspirin, Dipyridamole, high performance liquid chromatography.
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