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*Azman Ahmed, Rinong Rahim and Koo Idlan
Abstract: Ficus religiosa is being used in Ayurvedic and Malay traditional medicine for the treatment of various diseases including gastric ulcer. Considering the above claims, the present work was undertaken to validate the anti-ulcer potential of the ethanol extract of stem bark of F. religiosa against in vivo indomethacin- and cold restrained stress-induced gastric ulcer, and pylorus ligation assays. The extract (100, 200 and 400 mg/kg) significantly (P[...] Read More.
Keywords: Ficus religiosa, stem bark, ethanol extract, gastric ulcer, pylorus ligation, indomethacin, cold stress induced gastric ulcers, ulcer index.
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*Kamshad Forouhar, Dariush A. Pakraven and Reza Khan
Abstract: Ruta graveolens is known as Rue. R. graveolens extracts and essential oil are important areas in drug development with numerous pharmacological activities in many countries. For a long time R. graveolens has been used in traditional medicines for the relief of pain, eye problems, rheumatism and dermatitis. R. graveolens has recently been shown to have antibacterial, analgesic, anti-inflammatory, antidiabetic and insecticidal activities. Rutin, quercetin, psoralen, methoxypsoralen, rutacridone, rutacridone epoxide and gravacridondiol are phytochemical compounds which are reported from this plant. α-Pinene, limonene and 1,8-cineole were identified as the main monoterpene constituents for R. graveolens essential oil. Due to the easy collection of the plant and being widespread and also remarkable biological activities, this plant has become medicine in many countries especially in Mediterranean region. This article presents comprehensive analyzed information on the botanical, chemical and pharmacological aspects of R. graveolens.[...] Read More.
Keywords: Ruta graveolens, Rutaceae, pharmacology, phytochemistry.
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*Abdel Naguib, Ahmad Mubarak and V. S. Gamal
Abstract: The radical scavenging activity using 1,1-diphenyl, 2-picrylhydrazyl (DPPH) and cytotoxicity using sulphorhodamine B (SRB) assay of the aqueous methanolic extract of Tamarix nilotica (Ehrenb.) Bunge (Tamaricaceae) flowers and its subextracts (CHCl3, EtOAC and Pet.ether) were evaluated. Total phenolic and flavonoid contents were estimated using colorimetric assays. Ethyl acetate (EtOAc) showed the highest free radical scavenging activity with inhibitory concentration (IC50) 7.25 ± 0.86 µg/ml in addition to potential cytotoxic effect on liver cell carcinoma (Huh-7) (IC50 49.1 ± 0.96 µg/ml) whereas effect on lung cell carcinoma (A-549) was much lower (IC50: 137.9 ± 1.85 µg/ml). EtOAc had the highest flavonoid content (1.75 ± 1.5 mg/g QE) compared to other subextracts. These results indicated that ethyl acetate fraction contains bioactive compounds worthy of more sophisticated studies as free radical scavenger and cytotoxic agent.[...] Read More.
Keywords: Tamarix nilotica, cytotoxic activity, sulphorhodamine B (SRB) assay, scavenging activity, 1,1-diphenyl, 2-picrylhydrazyl (DPPH) assay, flavonoid, phenolic.
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*Shankar Salman, Khan V. Bachchan and Swami V. singh
Abstract: In existing study, we carried out an efficient record of the comparative antioxidant activity in methanolic extract of the selected parts (leaves, root and stem bark) of Aegle marmelos. Total content of phenol and flavonoid was quantitatively estimated in different parts of A. marmelos. The total phenolic contents varied from 9.8367 ± 0.0235 to 1.7281 ± 0.049 mg g-1. Total flavonoid contents were between 8.248 ± 0.029 to 1.087 ± 0.002 mg g-1. Free radical scavenging activity of different extracts was evaluated by using DPPH (1, 1 -Diphenyl- 2 -picryl hydrazyl) method. The highest free radical scavenging effect was observed in leaves with IC50 = 2.096µg ml –1. The effectiveness of radical scavenging activity of leaves extract was about 10 times greater than reference antioxidant butylated hydroxy toluene (BHT). The greater amount of phenolic compounds leads to more powerful radical scavenging effect as shown by methanolic extract of A. marmelos leaves.[...] Read More.
Keywords: Aegle marmelos, antioxidant, flavonoids, phenols, 1, 1 –diphenyl - 2 -picryl hydrazyl.
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*Shankar Salman, Khan V. Bachchan and Swami V. singh
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*Mujibur Abed, Rahman E. Shakib and Khan Ahmed
Abstract: The ethanol extract of the dried leaves of Mikania cordata (Family-Asteraceae) was investigated for its possible bioactive chemical groups and antinociceptive, cytotoxic and antibacterial activities in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 125 and 250 mg/kg body weight (p[...] Read More.
Keywords: Antimicrobial, antinociceptive, asteraceae, cytotoxic, Mikania cordata.
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*Moshood Musa, Ibrahim Mohammed and Murutala Achebe
Abstract: This study investigated the phytoconstituents in Neem (seed and flower), Jatropha curcas (stem and root bark) and grape (stem bark and leaves) in some selected solvents. Phytochemical screening revealed the presence of bioactive compound saponin in all the parts of the three plants in water extract only. Saponin was absent in other solvents used (ethanol, ethyl acetate, propan-2-ol, methanol, n-butanol and acetone). Ethanol, ethyl acetate and methanol were the most promising solvents to extract flavonoids in both the seed and flower of Neem plant. Acetone and ethanol were the most promising solvents to extract flavonoids in the stem bark of J. curcas. In the root bark of J. curcas, acetone and ethyl acetate were the most promising solvents to extract flavonoids. In grape (Citrus paradisi) leaves, ethanol, water and acetone were the most promising solvents to extract flavonoids. In the stem bark of grape, water, ethyl acetate and acetone proved promising as extraction solvents for flavonoids. All the parts of the plants studied were positive for alkaloid in ethanol and acetone extracts. The seed extract of Neem (Azadirachta indica) was strongly positive in ethanol only. Terpenoids were detected in ethyl acetate and n-butanol in all the parts of the three plants. Aged flower extract of Neem plant with pale pink colour could be exploited as a novel source of colourant. Volatile oil was not restricted to J. curcas stem and root barks, it was also present in C. paradisi stem and root barks. The nutritional significance, economic and toxicological implications of phytoconstituents analysed in the plants were discussed.[...] Read More.
Keywords: Phytomedicine, bioactive compounds, natural product, drug discovery, preventive medicine.
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文章
Dr. Tahir Mehmood Khan ,

 International Journal of Pharmacy and Pharmacology ISSN: 2326-7267 Vol. 8 (2), pp. 001-003, February, 2019. © International Scholars Journals

Editorial

 

Quality use of antidepressants: how Pharmacists can play their part

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Babalola C. P.*, Awoleye S. A., Akinyemi J. O. and Kotila O. A.
Abstract: Drug therapy is the most commonly used method of any disease treatment in general practice. However, the patterns of drug prescription are often inappropriate and the need for registration of these patterns is essential in an effort to improve prescription standards. Retrospective analysis of prescriptions written by various cadres in primary health care department with emphasis on primary health care centers, dispensaries and health posts in four randomly selected local government areas were collected over a period of one year (March 2006 to February 2007). Data was collected using a standardized WHO instrument for studies of rational drug use. The average number of drugs per encounter was 6.11 with 69.81% drugs prescribed by generic names. The use of antibiotics (50.10% of encounters) and injections (72.70% of encounters) was relatively high. About ninety four percent(94%) of drugs prescribed were from the essential drugs list. It is obvious that poly pharmacy is high at the grassroots level coupled with shortage of high skilled manpower. The use of antibiotics and injections is also very high. Recruitment of skilled personnel and continuing educational programs for primary health care workers is recommended.[...] Read More.
Keywords: Prescription pattern, injections, antibiotics, primary health care.
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Syed Wasif Gillani*, Syed Azhar Syed Sulaiman, Yaseen Khalid, Yelly Oktavia Sari, Mirza Baig and Atif Amin
Abstract: Sex is a natural and basic drive of human beings. In Malaysia, erectile dysfunction (ED) is a common problem, affecting 16 to 47% of men above 40 years old. Erectile dysfunction (ED) is a common complication of diabetics, with prevalence ranging between 27 and 75%. Knowledge and perception are essential precursors of ED related quality of life. A cross-sectional study was conducted in Pulau Pinang, Malaysia, to produce the preliminary information to compare the knowledge and the perception of diabetic and non diabetic population towards sexual activity and the effect of ED on quality of life. Population based survey includes the entire male respondent in the community with age of 18 years and above. Investigator personally approached the respondents and asked them to complete self administered and anonymous pre-validated questionnaire. Statistical package for social sciences (version 15®) was used to analyze the data by adopting chi-square, univariate and multivariate analysis, ANOVA, T-test techniques, respectively. Data was collected from 1700 males aged between 20 years and above with response rate of 88.35%. The mean total knowledge score obtained by diabetics was significantly (p[...] Read More.
Keywords: Diabetics mellitus, perception and quality of life, erectile dysfunction, erectile and diabetics, diabetics and quality of life, erectile dysfunction treatment.
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