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Research Article

Optimization of industrial production of rifamycin B by Amycolatopsis mediterranei. II. The role of gene amplification and physiological factors in productivity in shake flasks

El-Tayeb, O.M.¹*, Hussein, M. M. M.², Salama, A.A.² and El-Sedawy, H.F.¹

¹Microbial Biotechnology Center, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

²Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

, 2004, 3(1), 1-6;

Received : 17 Feb 2004 / Accepted : 25 Mar 2004 / Published : 17 Feb 2004

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Optimization of industrial production of rifamycin B by Amycolatopsis mediterranei. II. The role of gene amplification and physiological factors in productivity in shake flasks